@article {1346, title = {Diabetes: Exploring the Intersection of Metabolic Disorders, Lifestyle Factors and Herbal Remedies: A Review}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {11-17}, type = {Review Article}, chapter = {11}, abstract = {

A chronic metabolic disorder, Diabetes mellitus significantly poses a health challenge globally. The escalating prevalence of diabetes, coupled with concerns regarding the side effects of conventional antidiabetic drugs, has spurred increased interest in exploring alternative therapeutic approaches. Herbal medicines, deeply rooted in traditional healing practices, have emerged as promising candidates for managing diabetes. The objective of this review is to optimise the current scientific literature on herbal medicines employed as antidiabetic agents. The review encompasses an in-depth analysis of diverse medicinal plants which have potential for management of T2DM. The potential of these herbal remedies in improving insulin sensitivity, modulating glucose metabolism and mitigating diabetes-related complications are established. Furthermore, the review critically examines clinical studies evaluating the potency and safe usage of herbal medicines in diabetic populations. Emphasis is placed on highlighting the need for further research and addressing challenges associated with standardization and quality check of herbal preparation. The integration of herbal medicines into mainstream diabetes care is explored, considering the potential for synergistic use with conventional therapies. In nutshell; this review consolidates existing knowledge, sheds light on promising avenues for future research and emphasizes the significance of herbal medicines in the quest for effective, safe and sustainable antidiabetic interventions. The wealth of traditional wisdom encapsulated in these natural remedies presents a valuable resource in the pursuit of novel therapeutic strategies for diabetes management.

}, keywords = {Antidiabetic activity, Diabetes, Herbal plants, Metabolic Disorder, T2DM}, doi = {10.5530/pres.20251951}, url = {https://readarticle.org/lensarticle/diabetes-exploring-the-intersection-of-metabolic-disorders-lifestyle-factors-and-herbal-remedies-a-review/}, author = {Shweta Bhandari and Rahul Trivedi and Rajesh A. Maheshwari and Swetaba Besh and Maitri Mahant and Sapana Patil and Vishal Garg and Ram Singh} } @article {1417, title = {Modulatory Effects of Passiflora edulis on Liver Function, Lipid Profile and Adipokines in Fructose-Induced Metabolic Syndrome in Rats}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {April 2025}, pages = {571-576}, type = {Original Article}, chapter = {571}, abstract = {

Background: This research explores the restorative effects of Passiflora edulis extract counter to liver damage and metabolic disruptions caused by a high-fructose diet in female Wistar rats. Materials and Methods: The consumption of fructose resulted in increased levels of hepatic enzymes, signaling liver damage, along with notable changes in the lipid profile, including TG, TC and LDL and HDL all of which are characteristic of metabolic syndrome. Doses of 250, 500 and 1000 mg/kg of the Passiflora edulis extract were administered to evaluate its therapeutic potential. Results: The results demonstrated that extract meaningfully dropped SGPT and SGOT levels, suggesting liver protection, particularly at the higher doses (500 and 1000 mg/ kg). However, the 250 mg/kg dose did not have a substantial outcome on ALP levels, indicating that a higher dosage is needed for optimal liver protection. Additionally, extract improved lipid profiles by falling TG, TC and LDL levels, while boosting HDL, indicating its potential to correct lipid imbalances associated with metabolic syndrome. At higher doses, extract also improved adipokines levels, increasing adiponectin and decreasing leptin and resistin, which are linked to better insulin sensitivity and reduced inflammation. Histopathological analysis showed that extract mitigated liver damage, with the most significant improvement observed at the 1000 mg/kg dose, where the liver tissue appeared almost normal. Conclusion: These results suggest that extract has beneficial effects on liver function and metabolic disturbances, predominantly at higher doses, positioning it as a hopeful substance for treating metabolic syndrome-related conditions. Subsequent studies are needed to evaluate the underlying mechanisms and assess the long-term effects of extract in metabolic diseases.

}, keywords = {Adipolines, Fructose, Hepatic enzymes, Histopathological Analysis, Lipid profile, Metabolic Syndrome}, doi = {10.5530/pres.20252058}, author = {Kinjal P. Patel and Rajesh A. Maheshwari} }