@article {1346, title = {Diabetes: Exploring the Intersection of Metabolic Disorders, Lifestyle Factors and Herbal Remedies: A Review}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {11-17}, type = {Review Article}, chapter = {11}, abstract = {

A chronic metabolic disorder, Diabetes mellitus significantly poses a health challenge globally. The escalating prevalence of diabetes, coupled with concerns regarding the side effects of conventional antidiabetic drugs, has spurred increased interest in exploring alternative therapeutic approaches. Herbal medicines, deeply rooted in traditional healing practices, have emerged as promising candidates for managing diabetes. The objective of this review is to optimise the current scientific literature on herbal medicines employed as antidiabetic agents. The review encompasses an in-depth analysis of diverse medicinal plants which have potential for management of T2DM. The potential of these herbal remedies in improving insulin sensitivity, modulating glucose metabolism and mitigating diabetes-related complications are established. Furthermore, the review critically examines clinical studies evaluating the potency and safe usage of herbal medicines in diabetic populations. Emphasis is placed on highlighting the need for further research and addressing challenges associated with standardization and quality check of herbal preparation. The integration of herbal medicines into mainstream diabetes care is explored, considering the potential for synergistic use with conventional therapies. In nutshell; this review consolidates existing knowledge, sheds light on promising avenues for future research and emphasizes the significance of herbal medicines in the quest for effective, safe and sustainable antidiabetic interventions. The wealth of traditional wisdom encapsulated in these natural remedies presents a valuable resource in the pursuit of novel therapeutic strategies for diabetes management.

}, keywords = {Antidiabetic activity, Diabetes, Herbal plants, Metabolic Disorder, T2DM}, doi = {10.5530/pres.20251951}, url = {https://readarticle.org/lensarticle/diabetes-exploring-the-intersection-of-metabolic-disorders-lifestyle-factors-and-herbal-remedies-a-review/}, author = {Shweta Bhandari and Rahul Trivedi and Rajesh A. Maheshwari and Swetaba Besh and Maitri Mahant and Sapana Patil and Vishal Garg and Ram Singh} } @article {1398, title = {Exploring the Role of Phytoconstituents for Endocrine Disorder: A Review}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {April 2025}, pages = {402-410}, type = {Review Article }, chapter = {402}, abstract = {

The endocrine system consists of various glands responsible for secreting hormones that regulate metabolism, growth, reproduction, and other physiological processes. Disruptions in this system, termed endocrine disorders, are linked to numerous health issues, such as obesity, diabetes, cardiovascular diseases, and metabolic syndromes. Moreover, the significance of factors such as life stage, gender and dietary habits in influencing health risks associated with endocrine disruption cannot be overstated. Synthetic medications for these conditions often have adverse side effects like hypoglycemia and heart complications, highlighting the need for alternative treatments. Herbal and natural remedies have shown promise in managing these disorders due to their lower toxicity and minimal side effects. Phytochemicals and poly-herbal therapies are emerging as effective strategies for addressing endocrine and metabolic disorders, influencing molecular targets like AMP-Activated Protein Kinase (AMPK) and Nuclear factor erythroid-2- related factor (Nrf2). Specific disorders such as diabetes, Addison{\textquoteright}s disease, and hyperthyroidism are characterized by hormone imbalances, with molecular mechanisms involving insulin resistance, cortisol dysregulation, and thyroid dysfunction. Additionally, the role of factors such as life stage, gender, and dietary habits in modulating endocrine disruption-associated health risks is crucial. Natural products, including flavonoids, catechins, resveratrol, and terpenes, are being explored for their therapeutic potential in regulating hormone levels and improving metabolic health.

}, keywords = {AMPK, Cardiovascular diseases, Diabetes, Endocrine system, Herbal medicine, Hormone imbalance, Metabolic disorders, Natural Products, Obesity, Phytochemicals}, doi = {10.5530/pres.20252070}, author = {Shweta Bhandari and Rahul Trivedi and Vishal Garg and Ajay Saini and Manish Gupta and Ram Singh} } @article {1505, title = {Secondary Metabolite as Therapeutic Agents with Significant Highlight on Terpenoids}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {August 2025}, pages = {1-8}, type = {Review Article}, chapter = {1}, abstract = {

The belief that plants possess biologically active compounds with healing properties beneficial for treating various health conditions has endured since ancient times. The therapeutic importance of these plants highlights their vast potential for the discovery and development of new pharmaceuticals, attributed to their chemical constituents that positively impact human health. Numerous naturally occurring phytochemicals, both dietary and non-dietary, have demonstrated significant potential in preventing and treating various diseases. Secondary metabolites are organic compounds naturally produced by plants, microbes, and certain animals, serving vital roles that extend beyond essential survival functions. Compounds such as alkaloids, flavonoids, terpenoids, and phenolics have garnered considerable interest due to their varied chemical structures and powerful biological effects. They demonstrate a broad spectrum of pharmacological properties, including antidiabetics, anticancer, anti-inflammatory and antioxidant as well as antimalarial, which make them important therapeutic agents in contemporary medicine. Terpenoids, or terpenes, form the largest group of natural compounds and are known for their biological activities, making them valuable in the treatment of human diseases. In the present work we have highlight the potential therapeutic benefit of terpenoids. Among the secondary metabolites terpenoids having more potential to be therapeutic agents for various disorders. Over the past two decades, bioprospecting natural products from the marine environment has led to the discovery of hundreds of terpenoids with unique structures and promising bioactivities, with many more yet to be uncovered.

}, keywords = {anticancer, Antidiabetic, Antimalarial, Antioxidant, Secondary metabolites, Terpenoids}, doi = {10.5530/pres.20252366}, author = {Sarika Sapan Parekh and Rahul Trivedi and Divya Kanojia and Sweta Ba Besh and Maitri Mahant and Ghanshyam Ratilal Parmar} } @article {1496, title = {Terpenoids as Natural Anti-Inflammatory Agents: A Review of Their Biological Mechanisms}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {August 2025}, pages = {1-12}, type = {Review Article}, chapter = {1}, abstract = {

Body{\textquoteright}s Immune system biological response also known as inflammation and it is stimulated by varied factors such as pathogenic organisms, ruptured cells and toxic components. The given factors can initiate inflammatory reactions may be acute or chronic in many vital organs of the body and causing cellular damage. This damage in-turn gives rise to pathways of inflammatory signals associated with mediators of inflammation. Inflammation associated diseases are rapidly growing worldwide. The treatment use to suppress inflammatory reactions in the body is also linked with serious adverse effects. In the current decade use of phytochemicals is increased heavily across the globe being advantageous of lesser side effects and better potential in reducing inflammatory reactions. Phytochemicals are not essential nutrients required for sustaining life, but they possess significant properties that help prevent or fight certain common diseases. Terpenoids are a vast and structurally diverse group of natural secondary metabolites found in plants, derived from isoprene units (C-5), and linked to a variety of biological properties such as anti-oxidant, anti-inflammatory and anticancer. The present review highlights the pharmacological aspects of terpenoids with reference to suppression of inflammation. The work also emphasizes on role of terpenoids at molecular level to reduce the signalling pathways of inflammation with certain examples. In addition, future perspective on the use of terpenoids as therapeutic agents is also overviewed.

}, keywords = {Anti-inflammatory, Herbal medicine, Phytochemicals, Terpenoids}, doi = {10.5530/pres.20252308}, author = {Sarika Sapan Parekh and Rahul Trivedi and Divya Kanojiya and Sunil Bhaurao Baile and Parikh Riddhi Nimeshkumar and Mehta Sakshiben and Ghanshyam Ratilal Parmar} } @article {1326, title = {Unlocking the Therapeutic Potential of Terpenoids: A Roadmap for Future Medicine}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {October 2024}, pages = {698-705}, type = {Review Article}, chapter = {698}, abstract = {

The naturally produced plant-derived compounds, known as phytochemicals, are biologically effective and incorporated to reduce the risk of numerous human illnesses. The utilization of phytochemicals for traditional medicine or functional nutrition has likely existed for as long as human history itself. Plants may gather phytochemicals in a variety of sections, including the roots, seeds as well as leaves and fruits. Among all the phytochemicals class, terpenoids are renowned for its proven biological activities and found in enormous capacity in medicinal plants. Several studies report the use of terpenoids in a wide range of diseases and infections. Different classes of terpenoids showed a variety of biological activities in chronic disorders and autoimmune diseases such as hypertension, diabetes, arthritis and cancer. These classes of compounds are also used against cancer and infectious diseases. In the present study we mainly highlight the use of terpenoids in different diseases and its availability in nature as different class. The role of terpenoids in developing new medications and enhancing current treatment methods is significant. However, thorough and detailed research is still warranted to entirely recognize the pharmacological effects of several terpenoids.

}, keywords = {Phytochemicals, Secondary metabolites, Terpenes, Terpenoids}, doi = {10.5530/pres.16.4.81}, author = {Sarika Sapan Parekh and Ghanshyam Ratilal Parmar and Divya Kanojiya and Sunil Bhaurao Baile and Rahul Trivedi and Foram Bhatt} }