@article {1300, title = {Exploring the Antioxidant and Antiproliferative Properties of Four Medicinal Plants from Veracruz, Mexico for Urinary and Prostate Health}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {October 2024}, pages = {817-827}, type = {Original Article}, chapter = {817}, abstract = {

Background: C. scaber, P. aequale, S. oleraceus and S. racemosa play a vital role in traditional medicine in Veracruz, Mexico, known for their effectiveness in treating a wide range of health issues. Particularly noteworthy is their significant use in traditional medicine in Mexico for addressing urinary and prostate-related ailments. Objectives: The current study assesses the antioxidant and anti-proliferative properties of these species on the androgen-independent prostate cancer cell line PC-3. Materials and Methods: Methanolic and aqueous extracts of the selected plants{\textquoteright} parts were prepared and their chemical profiles were evaluated using 1H-RMN. Antioxidant activity was assessed using the DPPH and FRAP methods. The total phenolic content was determined using the Folin-Ciocalteu method. The antiproliferative activity on PC-3 and HPrEC cells was evaluated by the MTT method. Results: S. racemosa showed the highest antioxidant activity (84.90\% radical scavenging activity), attributed to the presence of flavonoids. However, the methanol extract of P. aequale had a better effect on the proliferation of PC-3 cells with an IC50 of 251.6 {\textmu}g/mL, additionally, it showed cytotoxicity at high concentrations (above 500 {\textmu}g/mL). The antiproliferative and cytotoxic effect observed is not associated with antioxidant activity or the presence of alkaloids. However, cytotoxicity also occurred in control cells (HPrEC) with an IC50 of 23.98 {\textmu}g/mL. Conclusion: The methanolic extract of P. aequale showed the highest antiproliferative activity against PC-3 cell line, an effect not related to its antioxidant activity and attributed to the presence of aliphatic, aromatics and aldehydes compounds identified by 1H-NMR in the extracts.

}, keywords = {Antioxidant activity, Antiproliferative activity, Costus scaber, Piper aequale, Serjania racemosa, Sonchus oleraceus}, doi = {10.5530/pres.16.4.94}, author = {Oscar Antonio S{\'a}nchez-Aguirre and Cynthia Fern{\'a}ndez-Pomares and Enrique Ju{\'a}rez-Aguilar and Alberto S{\'a}nchez-Medina and Leticia Margarita Cano-Asseleih} }