@article {1336, title = {Ethanolic Extract of aerial parts of Achyranthes aspera Attenuates Hepatotoxicity and Nephrotoxicity Induced by Cisplatin in Rat}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {60-69}, type = {Original Article}, chapter = {60}, abstract = {

Background: The chemotherapeutic agents used to treat cancer are known to possess potent adverse effects like nephrotoxicity and hepatotoxicity among others. Objectives: The aim of this current study happened to be the isolation of phytoconstituent from Achyranthes aspera and assess the protective effect of the compound against cisplatin-induced hepato- and nephrotoxicity in rats. Materials and Methods: Toluene: Ethyl Acetate (9:1) was used as the solvent system to isolate the phenolic compound from ethanolic extract of the leaves and stem of A. aspera. The isolated compounds were studied using mass spectroscopy, 1H NMR, FT-IR and UV. The effect of the isolated phenolic was assessed by study of various factors like body weight, organ weight, serum biomarkers and histopathological studies. Results: The treatment of cisplatin led to a significant increase the weight of the organs, hepatic and kidney biomarkers in serum suggesting toxicity whereas the the isolated component reversed the elevated levels (p\<0.05 compared to positive control). Conclusion: It could be concluded from the results that pretreatment with isolated component (coumarin) was able to attenuate the hepato-and nephron-toxicity induced by anticancer drug cisplatin.

}, keywords = {Achyranthes aspera, Cisplatin, Hepatotoxicity, Isolation, Nephrotoxicity}, doi = {10.5530/pres.20251905}, author = {Arijit Chaudhuri and Udichi Kataria and Anurag Dubey} } @article {1511, title = {Exploring the Pharmacological Potential of Achyranthes aspera (Latzeera): A Complete Investigation of its Anticancer, Anti-Microbial and Antioxidant Activities}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {August 2025}, pages = {1315-1327}, type = {Original Article}, chapter = {1315}, abstract = {

Background: A medicinal herb called Achyranthes aspera has been used for centuries to treat a wide range of illnesses. By assessing its antineoplastic, anti-microbial and antioxidant properties. This study sought to thoroughly explore Achyranthes aspera pharmacological potential. Materials and Methods: Antibacterial activity against a panel of bacterial strains was assessed using the disc diffusion method. To ascertain cell viability in cancer cell lines, anti-cancer activity was assessed using the MTT assay. The antioxidant activity of the plant extract was assessed by its capacity to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Results: Achyranthes aspera extract showed encouraging antibacterial efficacy against specific bacterial strains, however not as strong as the common antibiotic, ciprofloxacin. The MTT assay indicated possible anti-cancer efficacy by showing a notable dose-dependent reduction in cancer cell lines{\textquoteright} cell viability. Through the scavenging of free radicals, the extract from Achyranthes aspera also demonstrated strong antioxidant activity. Conclusion: The pharmacological potential of Achyranthes aspera is strongly supported by this investigation, confirming its historic use in treating a variety of illnesses. Promising antioxidant, antimicrobial and anti-cancer properties were demonstrated by the plant extract. In order to determine the bioactive components, clarify the underlying mechanisms of action, assess the protection and efficacy of Achyranthes aspera extracts in preclinical, clinical contexts, these findings call for additional research.

}, keywords = {Achyranthes aspera, Anti-cancer, Anti-microbial, Antioxidant}, doi = {10.5530/pres.20252314}, author = {Arijit Chaudhuri and Biswajit Dash and Ashish Sarkar and Afrin Alam and Ayush Garg and Shivani Devi and Ankita Sharma and Varsha Chauhan and Tanbeer Kaur and Yashna Bawa} }