@article {1282, title = {Phytochemical Analysis of Selected Indigenous Plants and Essential Oils by Gas Chromatography/Mass Spectrometry Dedicate Antibacterial, Anti-Proliferative and Anti-Inflammatory Activity}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {October 2024}, pages = {727-732}, type = {Original Article}, chapter = {727}, abstract = {

Background: Natural compounds from medicinal plants have received much attention and research as resources in developing of new drugs. The challenge of for developing antibacterial agent from natural products for the treatment of MERSA, fungal and viral disease. Materials and methods: This study analyzed the chemical composition of Artemisia judaica and Juniperus procera methanol extracts and three essential oils include lemongrass (Cymbopogon citratus), clove (Syzygium aromaticum (L.) merr and perry) and tea tree (Melaleuca alternifolia). Results: The obtained results revealed the presence of bioactive functional molecules that exert several biological properties like antibacterial, anti-proliferative and anti-inflammatory activities such as caryophyllene, eugenol, palmitic acid and limonene. Conclusion: It was concluded that, it is promising in development of a novel plant-based drugs for MERSA, anti-inflammatory and antioxidant activities for mangment of different pathological conditions

}, keywords = {Artemisia Judaica, Essential oils, GC/MS active compounds, Juniperus procera}, doi = {10.5530/pres.16.4.84}, author = {Fatma A. Eissa and Taha A. Kumosani and Elie K. Barbour and Nouf O. Alshareef and Khalid M. El-Say and Said S. Moselhy} } @article {1232, title = {Phytochemical Identification of Active Components of Some Medicinal Herbs and Oils Relative to its Biological Activities in Saudi Arabia}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {April 2024}, pages = {264-269}, type = {Original Article}, chapter = {264}, abstract = {

Background: Herbal medicine and its bioproducts are rich in bioactive compounds that promising in drug development. These phytochemical constituents may be secondary metabolites that exert high potency. Materials and Methods: This study investigated the phyto-constituents bioactive compounds from the aerial parts of some Saudi medicinal plants using n-hexane extracts (Trichodesma trichodesmoides, Baccharoides schimperi, Anabasis articulate and Achillea fragrantissima) and a mixture of essentials oils in equal ratio (Arnica montana, Chamomile, Salvia officinalis, Oenothera, Walnut leaves and Flaxseed) using GC-MS. Results: The GC-MS analysis of plants and essentials oils revealed the presence of various compounds like terpenoids and vitamins related to its anti-microbial activity, antioxidant and anti-inflammatory activity. Conclusion: It was concluded that, the broad range of terpenoids and vitamins are the main components in the hexane extract. These possess different biological activities. Further studies will be carried out in vivo and in vitro to identify the mechanism of action via signaling pathway.

}, keywords = {Bioactive compounds, Herbs, Oils, Terpenoids, Vitamins.}, doi = {10.5530/pres.16.2.33}, author = {Turkyah J. Al-Bogami and Elie K. Barbour and Abdulrahman L. Al-Malki and Taha A. Kumosani and Said S. Moselhy} } @article {1237, title = {Solvent Polarity from Different Plant Extracts Deticate the Potential Activity against Infection by Methicillin-Resistant Staphylococcus aureus in Saudi Arabia}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {April 2024}, pages = {300-304}, type = {Original Article}, chapter = {300}, abstract = {

Background: Skin infection by Methicillin-Resistant Staphylococcus aureus (MRSA) is a common disease in Saudi Arabia. This bacterium is resistance to Methicillin and other antibiotics. Skin and soft tissue are the greatest common infected areas by these strains include abscesses, wound infections and other diseases. Materials and Methods: This study evaluated the in vitro antibacterial action of different plants extracts using different solvents from Saudi Arabia against MRSA. Different Plants were extracted by different solvents: methanol, chloroform and n-hexane. Agar well diffusion method was used to determine antibacterial efficacy with 100 μL (5 mg /0.5 mL) of plant extracts. Results: Minimum inhibitory concentration was determined on plant extracts that showed high effectiveness against MRSA. Conclusion: The obtained from Gas chromatography/mass spectrum analysis of the most active four plants, revealed the active volatile oils and flavonoids contents of Artemisia monosperma, Mentha longifolia, Vernonia schimperi and Rumex nervosu have antibacterial activity against MRSA. These plants demonstrate promising anti-MRSA potential.

}, keywords = {Methicillin-Resistant, Plant extract., Solvent polarity, Staphylococcus aureus}, doi = {10.5530/pres.16.2.38}, author = {Taha A. Kumosani and Sharifah H. Alshehri and Fatma A. Eissa and Elie K. Barbour and Soonham S. Yaghmoor and Turkyah J. Albogami and Sultan N. Sunble and Tarek A. Abdelnapy and Said S. Moselhy} } @article {1163, title = {Possible Inhibition of Renal Protein Glycation by Carnosine and Tocopherol in Diabetic Rat}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {June 2023}, pages = {562-565}, type = {Original Article }, chapter = {562}, abstract = {

Background: Carnosine is a biological active dipeptide in different tissue exert physiological role as buffer in muscle and cell cycle division. Tocopherol (vitamin E) is the potent antioxidant natural product. This study investigated the role of carnosine supplementation with vitamin E in protection against nephropathy in diabetic rats. Materials and Methods: This study was carried out on 75 rats grouped into five groups; control and the other rats groups (II-V) were received a single dose of streptozocine i.p, at dose of (65 mg/kg/b.w) for diabetogenesis. GPI were considered as diabetic untreated. Rats in groups 3-6 were treated i.p daily with carnosine (1mg/kg b.w), vitamin E (50,00 IU/kg b.w) or combined (10 mg/kg b.w) respectively for 12 weeks. Fasting serum was subjected for assay of glucose, HbA1c, AGEs, MDA, SOD, total antioxidant activity and inflammatory markers (TNF-α and IL-6). Results: Data obtained showed that, diabetic rats treated with carnosine and Vitamin E showed improvement in glucose, glycated hemoglobin, antioxidant enzymes, decreased inflammatory mediators and AGEs (p \<0.001) versus untreated diabetic. In addition, combined treatment is better than individual treatment (p \<0.05). Conclusion: Promising positive results were spot a new strategy of carnosine and Vitamin E rich food supplements for protection against diabetic complications. It can be used as complementary and alternative therapy for nephropathy, neuropathy and cardiomyopathy.

}, keywords = {AGEs, Carnosine, Diabetic nephropathy, Inflammation, Rat., Vitamin E}, doi = {10.5530/pres.15.3.059}, author = {Etimad Huwait and Maryam A. Al-Ghamdi and Faisal S. Al-Shehri and Said S. Moselhy} }