@article {1297, title = {Exploring Antidepressant and Skeletal Muscle Relaxant Effects of the Hydroalcholic Extract of the Sedum lineare Thunb}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {October 2024}, pages = {803-809}, type = {Original Article}, chapter = {803}, abstract = {

Background: Sedum lineare is a perennial succulent plant that is a member of the family Crassulaceae. Objectives: The present study desired to explore the antidepressant and muscle relaxant activities of hydroalcoholic extract of Sedum lineare Thunb. Materials and Methods: Male Swiss Albino mice were selected and distributed on different groups and administered with extracts of various doses. The forced swim test, tail suspension test, grip strength test and inclined plane test were conducted. Results: The forced swim test showed a reduction in the immobility time, i.e., 124.6{\textpm}1.32, 98{\textpm}0.72 and 84.4{\textpm}1.20 at a dose of 100 mg/kg, 250 mg/kg and 500 mg/kg. The tail suspension test also presented reduced immobility time, i.e., 128{\textpm}1.61, 117.4{\textpm}0.96, 104.4{\textpm}0.63 in 100 mg/kg, 250 mg/kg and 500 mg/kg, respectively. The grip strength test showed a decrease in time to fall from the wire, i.e., 33.4{\textpm}0.92, 19.2{\textpm}0.86 and 15.2{\textpm}0.86 in 100 mg/kg, 250 mg/kg and 500 mg/kg, respectively. Time in the inclined plane also reduced, i.e., 20.8{\textpm}1.24, 17.2{\textpm}0.58, 14.8{\textpm}1.06 in 100 mg/kg, 250 mg/kg and 500 mg/kg, respectively. Conclusion: Hydroalcoholic extract of Sedum lineare Thunb possesses depression and muscle relaxant activities.

}, keywords = {Anti-depressant, Forced swim test, Muscle relaxant, Sedum lineare Thunb, Tail suspension test}, doi = {10.5530/pres.16.4.92}, author = {Sunil Kumar and Ajay Kumar Singh Rawat and Peeyush Bhardwaj} } @article {1105, title = {Formulation and in-vitro Antidiabetic Assessment of Plumbago zeylanica Root Extract Containing Tablet}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {December 2022}, pages = {56-63}, type = {Original Article}, chapter = {56}, abstract = {

The plant processed herbal formulation have significant role in drug discovery, same time phytoconstituents have high pharmacological potential to treat the various ailments such as diabetes or chronic hyperglycemia. The present research aims to explore and investigate the antidiabetic potential of roots of hyperglycemia Linn. During the study pharmacognosy and formulation of herbal tablet has been done. Fresh roots of plant were collected, two enzymes named as alpha-Amylase and alpha-Glucosidase were obtained from Sigma Aldric. Extraction and fractionation along with phytochemical screening was performed Herbal tablets were made using the direct compression method. The n-butanol fraction of plant extract was mixed with the excipients and compressed into tablets. Different batches of formulations were prepared by dry granulation technique. The maximum in vitro dissolution was found to be with formulation F2 that exhibit the extreme proportion of accumulative release of drug (93.96\%) due to the optimized concentration of PVP and Chitosan and the formulations F2 has potent Antidiabetic Activity and also have antioxidant potential that was performed in this study. Plant extract has been used to formulate herbal tablets. From all five batches of tablets one batch (F2) was found to be best formulation and this was used to investigate the Antidiabetic activity as well as antioxidant activity also. The plants have potential to treat hormonal disorders also hence it can be used to treat the endocrine metabolic disorders.

}, keywords = {Antioxidant, Chitosan, Endocrine, Hyperglycemia, in vitro, n-butanol., α-Amylase, α-Glucosidase}, doi = {10.5530/097484900211}, author = {Aakash Partap Singh and Sunil Kumar and Manjusha Chudhary and Dinesh Kumar and Beena Kumari and Bhuwanendra Singh and Renu and Manish Kumar} }