@article {1106, title = {Physiochemical Characterization and in vitro Evaluation of Formulated Herbal Bioactive Loaded Transdermal Patches}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {December 2022}, pages = {64-70}, type = {Original Article}, chapter = {64}, abstract = {

Aim: The present research aimed to formulate a transdermal patch incorporating herbal bioactive Vitex negundo extract. The polymers that were used for selected sustained release of the drug are HPMC, PVP K30 and polyethylene glycol used as a plasticizer. Materials and Methods: Transdermal patches were prepared using the drug with two (HPMC and PVP K30) different polymers. The prepared transdermal films were evaluated for their physico-chemical characteristics such as physical appearance, weight uniformity, thickness, folding endurance, moisture content, drug content, percent moisture loss and permeation studies. The skin irritation study done on rat skin showed that the formulation does not produce irritation to the skin it showed the successful release of drug from the fabricated patch. Results: The in vitro release of formulation F1, F2, F3, F4, F5 and F6 has shown release of about 89.15\%, 87.12\%, 82.34\%, 92.45\%, 86.78\% and 76.21\% at 8hr. The order of drug release was found to be F4\>F1\>F2\>F3\>F6\>F5. Conclusion: It could be concluded that it was concluded from the study, that the transdermal patch containing herbal bioactive Vitex negundo F4 batch showed the highest percent of drug release and other desirable properties can be developed.

}, keywords = {Differential Scanning Calorimetry (DSC), Fourier-Transform Infrared Spectroscopy (FTIR)., Physico-chemical properties, Stability, Transdermal, UV/Vis Spectroscopy}, doi = {10.5530/097484900244}, author = {Poojashree Verma and Neelesh Maheshwari and Deepika Bairagee} } @article {1104, title = {Phytotherapeutic Potential of Natural Herbal Medicines for Management of Psoriasis: Current Status}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {December 2022}, pages = {42-55}, type = {Review Report}, chapter = {42}, abstract = {

Psoriasis is a complex multifunctional inflammatory autoimmune skin disease, which is mainly characterized by activation of T-cell (T-lymphocyte), abnormal proliferation keratinocyte, local vascular changes and activation of the neutrophil. A number of therapies are being used to treat psoriasis including topical, systemic and phototherapy recpectively but none of them is able to cure the disease completely, precluding the long-term serious side effects for the human body. In contrast to these, herbal therapies can play an important role for treatment of psoriasis. With this endeavor, this review reports the recent developments and patent showing potential of herbal therapy for treatment of psoriasis along with future prospect in the field of traditional and novel drug delivery system (NDDS) for treatment of psoriasis.

}, keywords = {Herbal drug, Hyperproliferation, Keratinocyte, Novel drug delivery systems, Psoriasis}, doi = {10.5530/097484900261}, author = {Nupur Maheshwari and Neelesh Maheshwari and Dinesh Kumar Mishra and Anju Goyal} }