@article {1248, title = {Mechanistic Insights of a Natural Bioactive Compound: Apigenin}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {June 2024}, pages = {435-448}, type = {Review Article}, chapter = {435}, abstract = {

Apigenin, a natural bioactive compound belonging to the class of flavone, has emerged as a subject of intense scientific scrutiny due to its potential health benefits. This review provides mechanistic insights into the multifaceted actions of apigenin and its promising therapeutic applications. Widely distributed in various fruits, vegetables, and herbs, apigenin exhibits potent antioxidant properties, neutralizing free radicals and reactive oxygen species to combat oxidative stress and cellular damage. Its anti-inflammatory effects are attributed to the inhibition of pro-inflammatory mediators, suggesting potential in managing conditions like arthritis and inflammatory bowel disease. Notably, apigenin{\textquoteright}s ability to inhibit cancer cell proliferation, induce apoptosis, and reduce metastasis underscores its potential in cancer chemoprevention. Furthermore, apigenin{\textquoteright}s role in DNA repair and genoprotection may contribute to cancer prevention and maintenance of genomic stability. In neurodegenerative conditions, apigenin{\textquoteright}s antioxidant and anti-inflammatory actions show promise in protecting neurons and enhancing cognitive function. Additionally, its influence on cardiovascular health is evident through vasodilation, blood pressure reduction, and inhibition of platelet aggregation. While the current findings highlight the immense potential of apigenin in various health applications, further clinical research is necessary to establish its efficacy and safety in human therapeutics.

}, keywords = {Apigenin, Clinical research, Flavonoid, Health application, Mechanistic Insights, Natural bioactive}, doi = {10.5530/pres.16.3.53}, author = {Tushar Adhikari and Prerona Saha} } @article {1093, title = {Quantitative Estimation of Immunomodulatory Flavonoid Quercetin by HPTLC in Different Leafy Vegetables Available in West Bengal}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {423-428}, type = {Original Article}, chapter = {423}, abstract = {

Introduction: Leafy vegetables are commonly consumed medicinal plants used in various metabolic and infectious diseases. Additionally, their antiviral, antioxidant, anticancer, and antihypertensive activities have been reported in the literature. Objectives: To determine the quantity of immunomodulatory flavonoid, quercetin in different types of leafy vegetables available in West Bengal by using a simple validated HPTLC method. Materials and Methods: The chromatographic analysis was performed by using aluminium-backed silica gel 60 F254 plates with Toluene{\textendash}Ethyl acetate{\textendash}Formic acid 5:4:0.2 (\%v/v) as the mobile phase. The method was validated according to the ICH guidelines. Results: The total flavonoid content (TFC) in the four leafy vegetables studied varied between 58.10 to 12.28 mg QE/g. Well-separated and compact spots (Rf) of quercetin (0.55{\textpm}0.03) were detected. The regression equation obtained was y = 0.0011x - 0.0569, with a correlation coefficient (R{\texttwosuperior}) of 0.9939. The linearity range (μg/spot) was 60-160. The LOD/LOQ (ng/spot) was 6.09/18.47. Murraya koenigii (0.1992{\textpm}0.037 \%w/w) contained the maximum amount of quercetin compared to Ipomoea aquatic (0.1501{\textpm}0.039\%w/w), Coriandrum sativum (0.1430{\textpm}0.061\%w/w) and Trigonella foenum- graecum (0.1201{\textpm}0.055\%w/w) in methanolic extract. Conclusion: This study revealed that the validated HPTLC method was simple, accurate and sensitive for separating and quantifying quercetin in different leaf vegetables. Quercetin content was highest in Murraya koenigii (0.1992{\textpm}0.037 \%w/w), and least in Trigonella foenum-graecum (0.1201{\textpm}0.055 \%w/w). The developed method might be used further in standardizing and quality control of secondary metabolites in herbal formulations

}, keywords = {Flavonoid, HPTLC, Leafy vegetables, Quercetin}, doi = {10.5530/pres.14.4.62}, author = {Tushar Adhikari and Prerona Saha} }