@article {1313, title = {Development and Evaluation of Herbal-Enriched Nutraceutical Gummies for Pediatric Health}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {October 2024}, pages = {872-878}, type = {Original Article}, chapter = {872}, abstract = {

Background: Nutraceuticals, which combine the nutritional benefits of food with the therapeutic effects of pharmaceuticals, offer a promising approach to enhancing children{\textquoteright}s health and well-being. Among these, herbal-enriched nutraceuticals stand out due to their potential to deliver a range of health benefits derived from natural plant sources. Aim: This study aimed to develop gummies with Elettaria cardamomum, Amomum subulatum Roxb, Zingiber officinale, Beta vulgaris L. using different concentrations of gelling agents, plasticizers and pH modifiers. Materials and Methods: Gelatin was tested at concentrations of 8\% and 10\%. The objective was to assess concentration of gelling agents that affect the physical properties of the gummies, such as visual appearance, dispersion time, and texture profile (hardness, chewiness, and gumminess). The gummies were heated and allowed to set before being evaluated using a randomized method. The type and concentration of the gelling agents, as well as their interaction, had significant effects on dispersion time, appearance, hardness, gumminess, and chewiness. Conclusion: Gummies made with 8\% gelatine were found to be the best formulations, meeting all physical property requirements, showing no syneresis, and having the most pleasant texture.

}, keywords = {Amomum subulatum Roxb, Beta vulgaris L., Disintegration study, Elettaria cardamomum, Herbal gummies, Ph, Swelling ratio, Syneresis study, Zingiber officinale}, doi = {10.5530/pres.16.4.99}, author = {Kanchana Yadav and Nitin Motiram Gawai and Brijesh Shivhare and Laxman Sureshbabu Vijapur and Gaurav Tiwari} } @article {1080, title = {Development and Assessment of Phytophospholipid Nanovesicular Systems for Treatment of Diabetic Neuropathy}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {360-368}, type = {Original Article}, chapter = {360}, abstract = {

Background: Diabetic neuropathy (DN) is the most prevalent and problematic consequence of diabetes mellitus, with the highest rates of morbidity and death, as well as a significant financial burden on diabetes treatment. Aside from commercially available formulations, substantial research on herbal-based natural therapies to treat hyperglycemia and related consequences is underway. Objectives: The major aim of the study was to use an ethosomal gel to improve transdermal penetration of Curcuma longa and Boswellia serrata and to overcome the challenges of low transdermal drug delivery permeability. Materials and Methods: Curcuma longa and Boswellia serrata loaded ethosomes were made using a cold process with various amounts of ethanol and soya lecithin, and were improved based on entrapment efficiency, vesicular size, and ex-vivo investigations. Results: The optimized ethosomal formulation was then put into a gel and evaluated. Ex-vivo tests were conducted with Curcuma longa and Boswellia serrata ethosomal gels, which were compared to plain gel. The ethosomal system produced vesicles with sizes ranging from 1 to 100 nm, a spherical, smooth surface, and a maximum entrapment efficiency of Ne9. A modified ethosomal system (Ne9) was introduced into the gel and studied further. Conclusion: According to the findings, the ethosomal gel has a lot of potential for transdermal Curcuma longa and Boswellia serrata administration.

}, keywords = {Boswellia serrata, Curcuma longa, Drying studies, Ethosomal gel, Ethosomes, Ex-vivo studies}, doi = {10.5530/pres.14.4.54}, author = {Gaurav Tiwari and Deepa Yadav and Bhuwanendra Singh and Abhitendra Kumar and Pranay Wal and Ruchi Tiwari} }