@article {1242, title = {Evaluation of Mixer of Essential Oils and their Standard Components against Fungi Causing Superficial Mycosis in Human}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {April 2024}, pages = {339-346}, type = {Original Article}, chapter = {339}, abstract = {

Background: Dermatophytoses are responsible for almost one-quarter of all fungal infections globally. When treatable, these challenging fungal infections of the skin, hair, and nails are becoming more resistant to standard antifungal medications and frequently call for lengthy therapeutic regimens. Objectives: Essential oils have been used to cure a range of diseases for ages. In present study combination effect of volatile oils obtained from Trachyspermum ammi, Coriandrum sativum and Cymbopogon martinii were evaluated against four selected dermatophytic fungi namely Microsporum canis, M. fulvum, Trichophyton rubrum and T. mentarophytes. Materials and Methods: Four combinations like T. ammi + Cymbopogon martinii, T. ammi + Coriandrum sativum, Cymbopogon martinii + C. sativum, T. ammi + Cymbopogon martinii + C. sativum were prepared and evaluated through semisolid agar antifungal susceptibility methods. Results: During present investigation T. rubrum was found to be most resistant fungus. Combination of T. ammi with C. sativum showed excellent results as compared to T. ammi and C. martinii. Combination of C. martinii and C. sativum was less effective as compared to other combinations. MIC was ranging from 0.1 μL/mL to 0.4 μL/mL against test fungi. Conclusion: Although essential oils are frequently combined in the use of aromatherapy to cure infectious disorders, there is very little data to back up this practice. This study supports the concurrent usage of blended essential oils in some way.

}, keywords = {Combination, Dermatophytes, Essential oil, MIC.}, doi = {10.5530/pres.16.2.43}, author = {Neetu Jain} } @article {1058, title = {Comparative Analysis of Antidermatophytic Potential of Cymbopogon citratus Essential Oil Stored in Different Temperature Condition for Two Years}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {July 2022}, pages = {241-245}, type = {Original Article}, chapter = {241}, abstract = {

Background: Cymbopogon citratus commonly known as lemon grass is a valuable medicinal plant. In present investigation variation in the antidermatophytic potential of C. citratus essential oil was estimated in different temperature and storage periods. Materials and Methods: C. citratus essential oil was extracted through hydrodistillation methods and kept in amber bottles in three different temperature conditions like room temperature (variable from 8-45{\textdegree}C), refrigerator temperature(2-6{\textdegree}C) and 30{\textdegree}C for 2 years. Minimum inhibitory concentration was determined after every fourth month of storage against selected dermatophytes. Results: Antidermatophytic activity of C. citratus oil was found prominent due to high concentration of citral derivatives. MIC was found to be stable against Trichophyton rubrum (MTCC 296) (0.1μL/mL) and T. mentagrophytes (MTCC 7687) (0.1μL/mL) at the end of experiment in all three temperature conditions. 30{\textdegree}C temperature condition was also found quite stable. A very slight increase of MIC was found against Candida albicans (MTCC 3018) and Microsporum fulvum (MTCC 2837) at 24 months (Sixth testing) of storage. Oil stored at room temperature showed variation in MIC as compared to initial one. MIC was found to double against M. fulvum (MTCC 2837) at sixth testing (0.4μL/mL) of storage as compared to first testing (0.2μL/mL). Conclusion: Present work concluded that essential oil stored in low temperature condition can maintained their primary composition and properties for long time. Therefore, storing of essential oil products in low temperature (below 8{\textdegree}C) condition is best practices for long time application of medicinal products.

}, keywords = {C. citratus, Dermatophytes, Essential oil, Longevity, MIC, Storage}, doi = {10.5530/pres.14.3.34}, author = {Neetu Jain and Meenakshi Sharma} }