@article {1105, title = {Formulation and in-vitro Antidiabetic Assessment of Plumbago zeylanica Root Extract Containing Tablet}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {December 2022}, pages = {56-63}, type = {Original Article}, chapter = {56}, abstract = {

The plant processed herbal formulation have significant role in drug discovery, same time phytoconstituents have high pharmacological potential to treat the various ailments such as diabetes or chronic hyperglycemia. The present research aims to explore and investigate the antidiabetic potential of roots of hyperglycemia Linn. During the study pharmacognosy and formulation of herbal tablet has been done. Fresh roots of plant were collected, two enzymes named as alpha-Amylase and alpha-Glucosidase were obtained from Sigma Aldric. Extraction and fractionation along with phytochemical screening was performed Herbal tablets were made using the direct compression method. The n-butanol fraction of plant extract was mixed with the excipients and compressed into tablets. Different batches of formulations were prepared by dry granulation technique. The maximum in vitro dissolution was found to be with formulation F2 that exhibit the extreme proportion of accumulative release of drug (93.96\%) due to the optimized concentration of PVP and Chitosan and the formulations F2 has potent Antidiabetic Activity and also have antioxidant potential that was performed in this study. Plant extract has been used to formulate herbal tablets. From all five batches of tablets one batch (F2) was found to be best formulation and this was used to investigate the Antidiabetic activity as well as antioxidant activity also. The plants have potential to treat hormonal disorders also hence it can be used to treat the endocrine metabolic disorders.

}, keywords = {Antioxidant, Chitosan, Endocrine, Hyperglycemia, in vitro, n-butanol., α-Amylase, α-Glucosidase}, doi = {10.5530/097484900211}, author = {Aakash Partap Singh and Sunil Kumar and Manjusha Chudhary and Dinesh Kumar and Beena Kumari and Bhuwanendra Singh and Renu and Manish Kumar} } @article {953, title = {Antihistaminic activity of aqueous extract of stem bark of Ailanthus excelsa Roxb.}, journal = {Pharmacognosy Research}, volume = {3}, year = {2011}, month = {September 2011}, pages = {220-224}, type = {Original Article}, chapter = {220}, abstract = {

Background: Biologically active compounds from natural sources are of interest as possible new drugs for different diseases. Over many centuries humans have been mining the bounties of nature for discovering natural products that have been used for the treatment of all human diseases. Ailanthus excelsa Roxb. (Simaroubaceae) is widely used in the Indian system of medicine as an antiasthmatic, antispasmodic, bronchodilator, anticolic pain, anticancer, antidiabetic etc. The plant was also reported for its antiasthmatic, bronchodilatory, antiallegic and many more such activities. Objective: To evaluate the antihistaminic activity of aqueous extract of stem bark of Ailanthus excelsa Roxb. Materials and Methods: We have studied the effect of aqueous extract of stem barks of A. excelsa Roxb. at a doses 100 μg/mL in the isolated goat tracheal chain preparation in vitro and 100, 200, 400 mg/kg doses orally in passive paw anaphylaxis in rat, clonidine-induced catalepsy in mice models in vivo for its antihistaminic activity. Results: Aqueous extract of stem barks of A. excelsa Roxb. significantly (***P\<0.001) inhibits the percentage contraction at concentration of 100 μg/mL in goat tracheal chain preparation. A. excelsa Roxb. extract (100, 200, and 400 mg/kg oral) and dexamethasone (0.5 mg/kg, i.p.) also significantly reduced (**P\<0.01) the paw volume at fourth hour and the percentage inhibition was found to be 13.98\%, 28.49\%, 42.47\% and 46.77\% respectively. The aqueous extract of stem barks of A. excelsa Roxb. (100, 200, 400 mg/kg, p.o.) and chlorpheniramine maleate (10 mg/kg, i.p.) significantly inhibited (*P\<0.05, **P\< 0.01) clonidine-induced catalepsy in mice at 150 min after the administration of clonidine. Conclusion: The aqueous extract of stem bark of A. excelsa Roxb. possess significant antihistaminic activity (H1-antagonist) and can be attributed to bronchodilating, anti-inflammatory, adaptogenic activity etc. Hence detailed study needs to be conducted to evaluate the phytoconstituent responsible for the above mentioned results and their clinical efficacy in the treatment of related diseases.

}, keywords = {Ailanthus excelsa Roxb, antihistaminic activity, passive paw anaphylaxis}, doi = {10.4103/0974-8490.85014}, author = {Dinesh Kumar and ZA Bhat and P Singh and SS Bhujbal and RS Deoda} } @article {799, title = {Bronchodilator activity of Aqueous extract of Stem bark of Ailanthus excelsa Roxb}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {May 2010}, pages = {102-106}, type = {Original Article}, chapter = {102}, abstract = {

Biologically active compounds from natural sources are of interest as possible new drugs for infectious diseases. Ailanthus excelsa Roxb. has been used in Indian system of medicine in the treatment of asthma, bronchitis, cold, colic pain, etc. Stem bark of A. excelsa Roxb. has been used as a decoction in traditional claims. So, our traditional claims enforced us to evaluate its bronchodilator activity. We have evaluated its bronchodilator activity in milk-induced leukocytosis and eosinophilia, clonidine-induced mast cell degranulation, bronchoalveolar lavage fluid (BALF), and lung histopathology models. The aqueous extract of stem bark in doses of 100, 200, 400 mg/kg showed significant activity.

}, keywords = {Ailanthus excelsa Roxb., Bronchoalveolar lavage fluid, Bronchodilator}, doi = {10.4103/0974-8490.62955}, author = {Dinesh Kumar and SS Bhujbal and RS Deoda and SC Mudgade} }