@article {755,
	title = {Anticonvulsant and Anxiolytic Evaluation of Leaf Extracts of Ocimum gratissimum, a Culinary Herb},
	journal = {Pharmacognosy Research},
	volume = {2},
	year = {2010},
	month = {March 2010},
	pages = {36-40},
	type = {Original Article},
	chapter = {36},
	abstract = {<p class="rtejustify">Anticonvulsant and anxiolytic activities of leaf extracts and fraction of Ocimum gratissimum L. (Lamiaceae) were studied using seizures induced by pentylenetetrazol and open-field tests in mice. The results showed that the extracts and fraction increased the latency of tonic and tonic-clonic seizures and death and elicited 50\% protection against mortality. In the open-field test, the extracts and fraction decreased the frequency of line crossing, center square entries, rearing against a wall and grooming, whereas grooming duration and freezing frequency and duration were increased. Acute toxicity test in mice gave an oral LD <sub>50</sub> greater than 5000 mg/kg for the methanol extract. These findings suggest that extracts of this plant possess anticonvulsant and anxiolytic-like properties.</p>
},
	keywords = {Anticonvulsant, Anxiolytic, Ocimum gratissimum, Open field},
	doi = { 10.4103/0974-8490.60580},
	author = {CO Okoli and AC Ezike and OC Agwagah and PA Akah}
}
