@article {745, title = {The study of aqueous extract of Ficus religiosa Linn. on cytokine TNF-α in type 2 diabetic rats}, journal = {Pharmacognosy Research}, volume = {3}, year = {2011}, month = {April 2011}, pages = {30-34}, type = {Original Article}, chapter = {30}, abstract = {

Background:\ Chronic systemic inflammation is an early process in pathogenesis of type 2 diabetes. Hence the present study was aimed to investigate the effect of traditionally known plant\ Ficus religiosa\ on elevated glucose and inflammatory marker namely tumor necrosis factor (TNF)-α in type 2 diabetic rats.\ Methods:\ Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rat model. Aqueous extract of\ F. religiosa\ at a dose of 100 and 200 mg/kg was given orally to desired group of animals for a period of 4 weeks. After 4 weeks of drug treatment, parameters such as fasting blood glucose, postprandial blood glucose and TNF-α in serum were analyzed.\ Results:\ Aqueous extract of\ F. religiosa\ at both dose levels i.e., 100 and 200 mg/kg decreased the elevated glucose and TNF-α in type 2 diabetic rats. The extract at 200 mg/kg had more pronounced effect.\ Conclusion:\ Modulation of cytokine TNF-α by the aqueous extract of\ F. religiosa\ indicates that the anti-inflammatory and immunomodulatory property of the plant is related with its potential anti-diabetic activity.

}, keywords = {Ficus religiosa, Inflammation, TNF-α, type 2 diabetes}, doi = {10.4103/0974-8490.79112}, author = {H Kirana and MV Jali and BP Srinivasan} }