@article {764, title = {Anti-diarrhoeal Investigation from Aqueous Extract of Cuminum cyminum Linn. Seed in Albino Rats}, journal = {Pharmacognosy Research}, volume = {6}, year = {2014}, month = {May,2014}, pages = { 204-209}, type = {Original Article}, chapter = { 204}, abstract = {

Background: Cuminum cyminum Linn. (Umbelliferae), commonly known as Jeera. It is native from mediterranean region, but today widely cultivated in Asian countries. It has been reported to possess various medicinal properties and an important food ingredient. The seed of the plant are claimed for treatment of diarrhoea by various traditional practitioners. Objectives: Hence, the present investigation was undertaken to evaluate aq. extract of C. cyminum seeds (ACCS) against diarrhoea on albino rats. Materials and Methods: The animals were divided into five groups and the control group was applied with 2\% acacia suspension, the standard group with loperamide (3 mg/kg) or atropine sulphate (5mg/kg) and three test groups administered orally with 100, 250 and 500 mg/kg of ACCS. The antidiarrhoeal effect was investigated by castor oil induce diarrhoea model, prostaglandin E 2 (PGE 2 ) induced enteropooling model, intestinal transit by charcoal meal test. Results: The ACCS showed significant (P \< 0.001) inhibition in frequency of diarrhoea, defecation time delaying, secretion of intestinal fluid as well as intestinal propulsion as compared to control and the graded doses of tested extract followed dose dependent protection against diarrhoea. Conclusions: The study reveals that the ACCS is a potent antidiarrhoeal drug which supports the traditional claim.

}, keywords = {Antidiarrhoeal effect, Castor oil, Enteropooling model, Intestinal transit, Seed}, doi = { 10.4103/0974-8490.132596}, author = {Himanshu Bhusan Sahoo and Saroj Kumar Sahoo and Sarada Prasad Sarangi and Rakesh Sagar and Mohan Lal Kori} } @article {715, title = {Aphrodisiac Activity of Polyherbal Formulation in Experimental Models on Male Rats}, journal = {Pharmacognosy Research}, volume = {6}, year = {2014}, month = {March,2014}, pages = {120-126}, type = {Original Article}, chapter = {120}, abstract = {

Objective: To investigate the aphrodisiac potential of polyherbal formulations prepared from different parts of Tribulus terrestris, Curculigo orchioides, Allium tuberosum, Cucurbita pepo, Elephant creeper, Mucuna pruriens, and Terminalia catappa in Albino rats in specified ratio as suspension. Materials and Methods: The different concentrations of prepared polyherbal formulations i.e. 150, 300, and 600 mg/kg and sildenafil citrate as standard (5 mg/kg) and vehicle (control) were administered orally to rats (n = 6 animals per group) for 3 weeks. Mating behavior parameters in male rats was monitored in first week and third week week of treatment pairing with receptive females. After termination of drug treatment, the mating performance, hormonal analysis, sperm count, and testes-body weight ratio were also evaluated. Results: The polyherbal formulation showed a significant increase in mating behavior as well as mating performance, serum hormonal levels, sperm count, and testes-body weight ratio with dose-dependent relationship as compared to vehicle control. But the dose of 600 mg/kg of polyherbal formulation assumes closer resemblance of above parameters with the standard used. Conclusion: The results of the study strongly suggest that the polyherbal formulations have a good aphrodisiac activity on rats in the above experimental models, which may be an alternative weapon for various sexual dysfunctions in future.

}, keywords = {Aphrodisiac, Mating behavior, Polyherbal formulations, Serum hormonal levels, Sexual dysfunctions, Testes-body weight ratio}, doi = {10.4103/0974-8490.129029}, author = {Himanshu Bhusan Sahoo and Subhangkar Nandy and Aswini Kumar Senapati and Sarada Prasad Sarangi and Saroj Kumar Sahoo} }