@article {1411, title = {Evaluation of Pistachio Extract Standardized to 1\% Melatonin on Pentobarbital Sodium-Induced Sleep in Swiss Albino Mice}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {April 2025}, pages = {659-664}, type = {Original Article}, chapter = {659}, abstract = {

Background: Pistachios are rich in melatonin, vitamins and antioxidants, which are known to have potential sedative and hypnotic properties. Previous studies suggest that melatonin, a hormone involved in regulating the sleep-wake cycle, may enhance sleep quality. However, the sleep-inducing effects of pistachio extract combined with melatonin have not been extensively studied, especially in animal models. Objectives: The objective of this study was to evaluate the sleep-inducing effects of Pistachio extract containing 1\% melatonin on pentobarbital-induced sleep-in mice. Materials and Methods: Pistachios were extracted using ethanol in a Soxhlet apparatus. The extract was then formulated into doses of 100 mg/kg, 200 mg/kg and 300 mg/ kg body weight, each containing 1\% melatonin. Sleep was induced in mice by administering a pentobarbital injection at 30 mg/kg body weight. The sleep onset time and total sleep duration were measured across different experimental groups. Results: The results demonstrated significant sleep-enhancing effects in the experimental groups. Group III (100 mg/kg pistachio extract with 1\% melatonin) showed a reduced sleep onset time of 6.13{\textpm}1.05 min and prolonged total sleep duration to 93.4{\textpm}4.48 min. Group IV (200 mg/kg pistachio extract with 1\% melatonin) exhibited a sleep onset time of 5.89{\textpm}1.2 min and a sleep duration of 104.67{\textpm}4.8min, while Group V (300 mg/kg pistachio extract with 1\% melatonin) demonstrated a sleep onset time of 5.58{\textpm}1.4 min and a sleep duration of 109.48{\textpm}4.66 min. Conclusion: All three experimental groups demonstrated significant, dose-dependent sedative and hypnotic effects, significantly reducing sleep latency and increasing sleep duration. These findings suggest that pistachio extract, rich in melatonin, may effectively enhance sedative effects and improve sleep quality by reducing the time required to fall asleep and extending sleep duration.

}, keywords = {Melatonin, Pistachio, Sleep, Sleep duration Sleep on set time}, doi = {10.5530/pres.20252094}, author = {Hebbani Nagarajappa Shivaprasad and Sravani Thimmannagari and Tharun Mariswamy and Cherupalli Sree Ramya and Madhu Krishnamani and Gaurav Soni} } @article {699, title = {Effect of Coleus Forskohliiextract on Cafeteria Diet-induced Obesity in Rats}, journal = {Pharmacognosy Research}, volume = {6}, year = {2014}, month = {December,2013}, pages = { 42-45}, type = {Original Article}, chapter = { 42}, abstract = {

Background: Obesity is a metabolic disorder that can lead to adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance and also increases the risk of coronary heart disease, ischemic stroke and type 2 diabetes mellitus. This study was designed to determine the effect of Coleus forskohlii on obesity and associated metabolic changes in rats fed with cafeteria diet. Objective: The aim of this study was to evaluate antiobesogenic and metabolic benefits of C. forskohlii in cafeteria diet induced obesity rat model. Materials and Methods: Rats were randomly divided into five groups of six animals in each group and as follows: Normal pellet diet group; cafeteria diet group; cafeteria diet followed by 50 mg/kg/d Coleus forskohlii extract (CFE), 100 mg/kg/d CFE and 45 mg/kg/d orlistat groups, respectively. Indicators of obesity such as food intake, body weight and alteration in serum lipid profiles were studied. Results: Feeding of cafeteria diet induced obesity in rats. Administration of CFE significantly halted increase in food intake and weight gain associated with cafeteria diet. Development of dyslipidemia was also significantly inhibited. Conclusion: The observed effects validate that supplementation of CFE with cafeteria diet could curb the appetite and mitigate the development of dyslipidemia.

}, keywords = {Appetite, Cafeteria diet, cholesterol, Coleus forskohlii, Lipid profile}, doi = {10.4103/0974-8490.122916}, author = {Hebbani Nagarajappa Shivaprasad and Sushma Gopalakrishna and Bhanumathy Mariyanna and Midhun Thekkoot and Roopa Reddy and Boreddy Shivanandappa Tippeswamy} }