@article {102, title = {Banisterine Alleviates Morphine-based Nephrotoxicity by Antioxidant Property: An In vivo Study}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {May 2021}, pages = {137-142}, type = {Original Article}, chapter = {137}, abstract = {

Background: Banisterine (BAN) as an alkaloid agent has antioxidant properties. The morphine (MOR) with the character of free radical generation has an effective role on renal pathogenesis. Objectives: This investigation critically examines the effects of the BAN against MOR-induced damage to the kidneys of rats. Materials and Methods: Sixty-four male Wistar rats were randomly assorted into 8 groups (8 rats in each), including the saline (Sal), MOR, BAN (5, 10, 15 mg/kg) and MOR + BAN treatment groups. All experimental procedures were applied by intraperitoneal injection daily for 20 days. Whole investigated values consist of total animal weight, weight of kidney, morphological criteria of kidney, antioxidant capacity and serum nitrite oxide levels. Results: Intraperitoneally MOR application significantly increased the levels of renal Malondialdehyde (MDA), blood urea nitrogen (BUN), blood creatinine, and blood nitrite oxide and also reduced the glomerular number and tissue ferric reducing/antioxidant power (FRAP) level compared to the Sal control group (P \< 0.05). Treatment of BAN and BAN + MOR in all doses significantly reduced the levels of BUN, MDA, creatinine, glomerular diameter, and nitrite oxide and also increased the glomerular number and tissue FRAP levels compared to the MOR group (P \< 0.05). Conclusion: The findings support the idea that the BAN with its antioxidant nature can eliminate MOR renal toxicity.

}, keywords = {Antioxidant, Banisterine, in vivo, Morphine, Nephrotoxicity}, doi = {10.4103/pr.pr_97_19 }, author = {Mohammad Reza Salahshoor and Cyrus Jalili and Amir Abdolmaleki and Shiva Roshankhah} } @article {130, title = {Antioxidative Properties of Thymus vulgaris on Liver Rats Induced by Paclitaxel}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {August 2019}, pages = {315-320}, type = {Original Article}, chapter = {315}, abstract = {

Background: Thymus vulgaris (Thym) is a species of flowering plant in the mint family Lamiaceae with potent antioxidant, and it has been beneficial effects during short-term administration. Paclitaxel sold under the brand name Tax (Tax) is chemotherapy drug which capable to produce free radicals. Objective: This study was designed to evaluate the effects of Thym against toxic effects of Tax to the liver of rats. Materials and Methods: Sixty-four male rats were assigned to eight groups: Control normal and Tax control groups (20 mg/kg); Thym groups (4.5, 9, 18 mg/kg), and Tax + Thym-treated groups (4.5, 9, 18 mg/kg). Treatments were administered intraperitoneally daily for 2 weeks. Griess technique was assessed for determined serum nitrite oxide (NO) level. Aspartate aminotransferase, ALANINE aminotransferase, and alkaline phosphatase concentrations were determined for liver functional disturbances. In addition, liver malondialdehyde (MDA), total antioxidant capacity (TAC), the diameter of hepatocytes, and the central hepatic vein (CHV) were investigated. Results: Tax administration significantly improved liver MDA and NO level, the mean diameter of CHV and hepatocyte, liver enzymes, and decreased TAC level compared to the normal control group (P \< 0.001). The Thym and Thym + Tax treatments at all doses significantly reduced the mean diameter of hepatocyte and CHV, liver enzymes, liver MDA, and NO levels and increased TAC level compared to the Tax control group (P \< 0.001). Conclusion: It seems that Thym administration improved liver injury induced by Tax in rats.

}, keywords = {Liver, Oxidative stress, Paclitaxel, Thymus vulgaris.}, doi = {10.4103/pr.pr_45_19}, author = {Mohammad Reza Salahshoor and Shiva Roshankhah, Cyrus Jalili} }