@article {638, title = {Anti-inflammatory and Anti-hyperalgesic Activities of Acanthopanax Trifoliatus (L) Merr Leaves}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {April 2013}, pages = {129-133}, type = {Original Article }, chapter = {129}, abstract = {

Context:Acanthopanax trifoliatus\ is a ginseng-like plant, which has been widely used to treat various diseases including inflammatory-related diseases.\ Aims:\ The present study has been designed to investigate the anti-inflammatory and anti-hyperalgesic effects of various fractions of\ Acanthopanax trifoliatus\ leaves ethanolic extract in rats.\ Materials and Methods:\ Anti-inflammatory activity was studied by using carrageenan-induced edema on rat paw whilst anti-hyperalgesic was assessed by using carrageenan-evoked thermal hyperalgesia on plantar test.\ Statistical Analysis Used:\ Data were analyzed using Student\ t-test to compare with control.Multiple comparisons for difference between control and extract-treated groups were evaluated by Tukey HSD (Honestly Significant Difference) test.\ P\ values less than 0.05 (P\ \< 0.05) is considered significant.\ Results:\ Among three different fractions i.e., hexane, dichloromethane, and methanol tested, methanolic fraction displayed the most potent fraction amongst those three. It gave significant anti-inflammatory effect at highest dose, 500 mg/kg, with 77.24\% of inhibition. Whilst for anti-hyperalgesic activity, methanolic fraction showed the highest efficacy at 375 mg/kg. Administration of methanolic fraction of\ Acanthopanax trifoliatus\ inhibited paw edema in a dose- dependent manner. The inhibition for both activities might be due to possible composition of polar compounds, which are flavonoids and phenolics content.\ Conclusions:\ Methanol fraction of\ Acanthopanax trifoliatus\ leaves has potential effect as anti-inflammatory and anti-hyperalgesia in acute inflammation model.

}, keywords = {Acanthopanax Trifoliatus, Anti-hyperalgesic Carrageenan-evoked Thermal Hyperalgesia, Plantar Test}, doi = {10.4103/0974-8490.110544 }, author = {Roslida Abdul Hamid and Teoh Hui Kee and Fezah Othman} }