@article {564, title = {The evaluation of the activity of medicinal remedies of plant and animal origin on the regeneration of the earthworms{\textquoteright} tail segments}, journal = {Pharmacognosy Research}, volume = {7}, year = {2015}, month = {October 2015}, pages = {393}, type = {Original Article}, chapter = {393}, abstract = {

Now, in the global community there is enough hard recommendation to replace the vertebrate test animals into simpler organisms at the development, testing, and evaluation of the quality pharmaceuticals. The feature of planarian to regenerate in new individual planarian from a piece, which is only 1/7 of the original animal, allowed to create the alternative methods of testing of drugs, dietary supplements, water quality, influence of electromagnetic fields, and other radiations. The tests on planarian can replace the ones that are held today on mammals. However, the lacks of the bioassays based on the planarian regeneration are the need for complex and expensive video equipment for recording the regrowth of worms{\textquoteright} body, the difficulties of culturing of flatworms and fairly long period of response. These difficulties can be avoided by using another group of the worms of type Annelida. The new individual can be fully recovered only from the front half of the body in many species of earthworms. Thus, the influence of the pharmaceuticals from earthworms, mummy, and Orthilia secunda on the ability of earthworms to regenerate lost tail segments has been investigated. The relations of the activity of preparations tested with doses and the time of the storage have been revealed. The principal possibility of applicability of the test reaction studied as a way to evaluate the effects and quality of remedies based on medicinal plants and earthworms has been shown.

}, keywords = {Earthworms, Medicinal remedies, Mummy, Orthilia secunda, Regeneration, Test-reaction, Vermipreparation.}, doi = {10.4103/0974-8490.159581}, author = {Viktor Alexandrovich Bybin and Daevard Iosifovich Stom} } @article {757, title = {The Influence of Pharmaceutical Vermipreparations on the Test-Reaction of Organisms of the Different Levels of the Organization}, journal = {Pharmacognosy Research}, volume = {6}, year = {2014}, month = {May,2014}, pages = {195-198}, type = {Original Article}, chapter = {195}, abstract = {

The efficiency of vermipreparations has been investigated with the help of the test-reactions on various invertebrate organisms, plants and microorganisms. The principal possibility of the use of biotest on the basis of yeast, fungi, algae, water and ground-based plants, sponges, protozoan, small crustaceans, oligochaetes for an estimation of biological activity of vermipreparations and in further and for definition of quality, selection of dose of medicinal complex preparations is shown.

}, keywords = {Algae, Earthworms, fungi, Oligochaetes, Plants, Protozoan, Small crustaceans, Sponge, Test-reaction, Vermipreparations, Yeast}, doi = { 10.4103/0974-8490.132594}, author = {Daevard I. Stom and Viktor Alexandrovich Bybin and Alla E. Balayan and Michael N. Saksonov and Valentina P. Salovarova} }