@article {123, title = {In vitro Antioxidant and Antidiabetic Activities of Leaf and Flower Extracts from Bombax ceiba}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {May 2020}, pages = {194-198}, type = {Original Article}, chapter = {194}, abstract = {

Context: Bombax ceiba is belonging to the family Bombacaceae. Dried stamen of this plant is used as vegetable and food ingredients for people in the Northern part of Thailand. There are very few reports on the biological activities in this plant, especially the flower parts. Objectives: The present study aimed to demonstrate the phytochemical screening and in vitro antioxidant and antidiabetic activities of crude extracts from B. ceiba. Materials and Methods: The leaf and flower part of B. ceiba were extracted using different solvents including water, 50\% ethanol, and 95\% ethanol. The phytochemical constituents were determined using standard qualitative methods. Total phenolic content (TPC) and total flavonoid content (TFC) were analyzed by colorimetric methods. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, 2,2-azino-bis-(3-ethylbenzothaizoline-6-sulphonate (ABTS) assay, and ferric reducing antioxidant power (FRAP) assay were used to investigate the in vitro antioxidant and antidiabetic activities of the extracts. For in vitro antidiabetic activities, α-glucosidase and α-amylase inhibitory effects were tested. Results: Phytochemical screening indicated the presence of alkaloids, flavonoids, coumarins, saponins, tannins, terpenoids, and cardiac glycosides in this plant. The highest TPC and TFC were found in 95\% ethanol flower extract (2.73 {\textpm} 0.064 mg gallic acid equivalent/g and 28.25 {\textpm} 2.33 mg quercetin equivalent/g, respectively.). However, the highest antioxidant activity (DPPH and ABTS + assay) was found in 95\% ethanol leaf extract (0.012 {\textpm} 0.0003, 0.009 {\textpm} 0.0005 mg/mL, respectively.) and FRAP assay was found in 95\% ethanol flower extract (349.27 {\textpm} 35.16 mg trolox equivalent/g). The highest α-glucosidase and α-amylase inhibitory activities were found in 95\% ethanol flower extract (0.001 {\textpm} 0.0012 and 0.0002 {\textpm} 0.0001 mg/mL, respectively). Conclusion: The crude extracts from B. ceiba showed the potent in vitro antioxidant and antidiabetic activities, especially the flower extracts. These findings confirm the ethnobotanical uses of B. ceiba as food and medicinal plants. Further studies on biological and pharmacological activities of this plant in the animal model and clinical trials must be carried out to confirm the use in medical aspects.

}, keywords = {Bombax ceiba leaf and flower extracts, In vitro antidiabetic inhibitory activity, In vitro antioxidant activity, Phytochemical screening}, doi = {10.4103/pr.pr_116_19}, author = {Nurarat Kriintong and Teeraporn Katisart} } @article {90, title = {Acute Toxicity of Flower Extracts from Dolichandrone serrulata in Mice}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {August 2019}, pages = {230-235}, type = {Original Article}, chapter = {230}, abstract = {

Context: Dolichandrone serrulata flowers are widely used as vegetables in northern and eastern Thailand. However, there is no report on the toxicities of this plant. Objective: The present study was aimed to determine the acute toxicity of aqueous flower extracts from D. serrulata in ICR mice. Materials and Methods: The extract at dose of 1000, 1500, and 2000 mg/kg was orally administered once to mice in order to investigate an acute toxicity. Results: The extract did not produce any sign or symptom of toxicity. Dead mouse was not found within the first 24 h and for further 14 days. The body weight increased in comparison to the controls. However, the relative organ weight between the treated and control mice was not different. The hematological values were not altered by the treatment of the extracts. The liver function parameters including aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase among treated mice were not different. The extract did not alter the kidney function parameters (blood urea nitrogen and creatinine). The lipid profiles in treated mice were not changed in comparison to the controls. In addition, histopathological features of the liver and kidney are not altered by the administration of the extracts. Conclusion: The results demonstrated that the maximum dose of D. serrulata flower extracts (2000 mg/kg) does not cause the acute toxicity in male and female mice.

}, keywords = {Acute toxicity, Aqueous extracts, Dolichandrone serrulata, Flower, Mice.}, doi = {10.4103/pr.pr_42_19}, author = {Teeraporn Katisart and Ampa Konsue} }