@article {1481, title = {Accelerated Stability Study of Powder Formulation Safoof Muqliyasa and Safoof Mulayyin}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {August 2025}, pages = {1-21}, type = {Original Article}, chapter = {1}, abstract = {

Background and Objectives: Evaluation of stability studies of Unani Medicine (UM) formulations determined on the basis of scientific data are the need of the time and also recommended in D and C Act. There is immense need to evaluate precise shelf life for each powder formulations. Materials and Methods: Accelerated Stability Study (ASS) of Safoof Muqliyasa (S. Muq) and Safoof Mulayyin. (S. Mul) was carried out with at elevated temperature and humidity conditions 40{\textordmasculine}C{\textpm}2{\textordmasculine}C with Relative Humidity of 75\%{\textpm}5\% RH according to ICH guidelines, by keeping in stability chamber in containers used by commercial UM. Pharmacy{\textquoteright}s (i.e. sealed HDPE containers). Testing frequency of samples was 0, 3 and 6 months and was subjected to various organoleptic, physical, microbiological and chemical tests parameters with HPLC quantification of active constituents/markers (Chebulic acid in S. Muq and Gingerol in S. Mul). Results were accessed as per API guidelines and are also statistically analyzed for 10\% degradation, from liner regression equation using individual slope and Intercept. Results: Both S. Muq and S. Mul were suitable at accelerated condition upto 3 month storage on selected physical, microbiological and chemical parameters as per API evaluation guidelines, and it can be extrapolated that real time shelf life period (predicted stability) according to Grimm{\textquoteright}s statement, for zone III and IV, 3.3 as 10 month at room temperature and packaging method adopted in the study and by 10\% degradation in different parameters by multiplying factor of 3.3 accelerated stability of Safoof Muqliyasa can be extrapoled as 2 years and 1 month and for Safoof Mulayyin 1 year and 5 months. Conclusion: According to physical and microbiological parameters both S. Muq and S. Mul are stable for 6 months in ASS but changes in selected chemical parameters was observed for after 3rd month making it stable approximately for 1 year. Stability of salt containing S. Mul was found to be comparatively lower than the non-salt containing S. Muq This observation/ shelf life may be exclusive to both the powders.

}, keywords = {Accelerated stability study, Powder, Safoof Mulayyin, Safoof Muqliyasa, Stability, Unani}, doi = {10.5530/pres.20252160}, author = {Md Naquibuddin and Hamiduddin and Gazi Jahangeer Rather and Fakeha Firdous Khanbhadur and Mohammed Saad} } @article {1164, title = {Formulation and in vitro Evaluation of Tablet Dosage form of Unani Anti-diabetic Powder Containing Gymnema sylvestre R. Br, Syzygium cuminii Linn. and Zingiber officinale Rosc.}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {June 2023}, pages = {566-577}, type = {Original Article }, chapter = {566}, abstract = {

Background and Objectives: Diabetes Mellitus (DM) is one of the leading causes of end stage renal disease, adult blindness etc. The side effects and resistance of conventional medicines for DM had put forward a need to develop an effective antidiabetic formulation with the aid of traditional medicine. Modification of dosage form in traditional system of medicine for palatability and portability is the need of hour. The antidiabetic safoof(powder) formulation containing Gurmar buti(Gymnema sylvestre R.Br), Jamun (Syzygium cuminii Linn.) and Zanjabeel (Zingiber officinale Rosc.) is having inconvenience to follow the accurate dose, palatability and stability issues due to surface area of powder. To rectify this problem the Safoof is modified into tablet dosage form with documentation of standard manufacturing procedure, its physicochemical analysis and in vitro antidiabetic evaluation. Materials and Methods: For process standardization total 10 batches were generated for the optimum working process related to the powder size, quantity of binder, wetting, granulation, time for drying and compression by trial and error. Ideal batch was selected on the basis of set parameter (friability, hardness and disintegration time), its physicochemical standards including HPLC as well as α-amylase and α-glucosidase inhibition activity were established. Results: With excipients 5\% Gum acacia, 5\% CMC, 1\% SSG, 0.5\% Mg stearate and 0.5\% Talc, the mean value of the hardness, friability and disintegration time of tablet were found to be 4.83 {\textpm} 0.17, 0.29 {\textpm} 0.01 and 14.24 {\textpm} 0.05 respectively. Physico-chemical data with HPLC quantification of Gymnemagenin, 6-Gingerol, 8-Gingerol, 6-Shogaol and 10-Gingerol were set in. The heavy metals and microbial contaminations are within permissible limit. Antidiabetic activity through α-amylase and α-glucosidase inhibition were 0.00 {\textpm} 0.00 at the 2500 μg/ml and 84.28 {\textpm} 0.58\% at the 3000 μg/ml concentration respectively. Conclusion: Classical powder is modified effectively in tablet dosage form with in vitro evaluation of its antidiabetic activity particularly α-glucosidase inhibition of crude powder and standardization data was also set in.

}, keywords = {Diabetes mellitus, Physico-chemical standardization, Powder, Tablets, α-glucosidase.}, doi = {10.5530/pres.15.3.060}, author = {Gazi Jahangeer Rather and Hamiduddin and Mohd Ikram and Md. Naquibuddin} }