@article {1297, title = {Exploring Antidepressant and Skeletal Muscle Relaxant Effects of the Hydroalcholic Extract of the Sedum lineare Thunb}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {October 2024}, pages = {803-809}, type = {Original Article}, chapter = {803}, abstract = {

Background: Sedum lineare is a perennial succulent plant that is a member of the family Crassulaceae. Objectives: The present study desired to explore the antidepressant and muscle relaxant activities of hydroalcoholic extract of Sedum lineare Thunb. Materials and Methods: Male Swiss Albino mice were selected and distributed on different groups and administered with extracts of various doses. The forced swim test, tail suspension test, grip strength test and inclined plane test were conducted. Results: The forced swim test showed a reduction in the immobility time, i.e., 124.6{\textpm}1.32, 98{\textpm}0.72 and 84.4{\textpm}1.20 at a dose of 100 mg/kg, 250 mg/kg and 500 mg/kg. The tail suspension test also presented reduced immobility time, i.e., 128{\textpm}1.61, 117.4{\textpm}0.96, 104.4{\textpm}0.63 in 100 mg/kg, 250 mg/kg and 500 mg/kg, respectively. The grip strength test showed a decrease in time to fall from the wire, i.e., 33.4{\textpm}0.92, 19.2{\textpm}0.86 and 15.2{\textpm}0.86 in 100 mg/kg, 250 mg/kg and 500 mg/kg, respectively. Time in the inclined plane also reduced, i.e., 20.8{\textpm}1.24, 17.2{\textpm}0.58, 14.8{\textpm}1.06 in 100 mg/kg, 250 mg/kg and 500 mg/kg, respectively. Conclusion: Hydroalcoholic extract of Sedum lineare Thunb possesses depression and muscle relaxant activities.

}, keywords = {Anti-depressant, Forced swim test, Muscle relaxant, Sedum lineare Thunb, Tail suspension test}, doi = {10.5530/pres.16.4.92}, author = {Sunil Kumar and Ajay Kumar Singh Rawat and Peeyush Bhardwaj} } @article {343, title = {Central Nervous System Activity of Phenol-Rich Fraction of Piper sylvaticum Roots}, journal = {Pharmacognosy Research}, volume = {10}, year = {2018}, month = {October 2018}, pages = {339-342}, type = {Original Article}, chapter = {339}, abstract = {

Obective: Piper sylvaticum Roxb. is an important folk medicine in Indian Traditional System of Medicine widely used by different tribes in many countries. In the present study, the anticonvulsant activity of extract/fractions of Piper sylvaticum (PS) roots was investigated. Materials and Methods: 70\% ethanolic extract of PS roots was successively extracted using hexane and ethyl acetate to prepare various fractions. Total phenol content was found at maximum 324.65 mg/gallic acid equivalent/g in ethyl acetate fraction (EAF) (phenol-rich fraction [PRF]). High-performance thin-layer chromatography fingerprinting profiling of PS roots was performed. The anticonvulsant properties of the EAF of roots of PS were examined by maximal electroshock method as compared to standard phenytoin (25 mg/kg body weight). Result: It was found that EAF shows potent anticonvulsant activity at different dose levels against maximum electroshock seizure-induced convulsions in Swiss albino mice. Conclusion: From the observation, it can be concluded that the current study has expressed that the phenol-rich EAF of the ethanolic extract of the roots of PS has shown the dose-dependent anticonvulsant effect in mice. The anticonvulsant potential may be due to the presence of phenolic compounds in PRF. The outcomes suggested a high potential for application of EAF of PS root as an anticonvulsant agent.

}, keywords = {Anticonvulsant activity, High-performance thin-layer chromatography, Piper sylvaticum, Piperine}, doi = {10.4103/pr.pr_125_17}, author = {Akash Ved and Amresh Gupta and Om Prakash and Ajay Kumar Singh Rawat} } @article {875, title = {Antimicrobial Screening of Ethnobotanically Important Stem bark of Medicinal Plants}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {September 2010}, pages = {254-257}, type = {Original Article}, chapter = {254}, abstract = {

Background: The stem barks are the rich sources of tannins and other phenolic compounds. Tannins inhibited the growth of various fungi, yeast, bacteria and virus. Hence, ten stem barks of ethnomedicinally important plants were screened for antibacterial and antifungal activities against human pathogenic strains. Methods: Air-dried and powdered stem bark of each plant was extracted with 50\% aqueous ethanol, lyophilized and the dried crude extracts were used for the screening against 11 bacteria and 8 fungi. Antibacterial and antifungal activities were performed according to microdilution methods by NCCLS. Results: The plants Prosopis chilensis, Pithecellobium dulce, Mangifera indica showed significant antibacterial and antifungal activities against Streptococcus pneumonia, Enterobacter aerogenes, Klebsiella pneumonia and Candida albicans with MIC of 0.08mg/ml. Pithecellobium dulce bark also showed significant antibacterial activity against Bacillus cereus. Conclusion: The bark of Pithecellobium dulce has more or less similar activity against the known antibiotic and may be considered as potent antimicrobial agent for various infectious diseases.

}, keywords = {Antibacterial, Antifungal, Bark, Ethnobotany, MIC}, doi = {10.4103/0974-8490.69127}, author = {Meenakshi Singh and Sayyada Khatoon and Shweta Singh and Vivek Kumar and Ajay Kumar Singh Rawat and Shanta Mehrotra} }