@article {343, title = {Central Nervous System Activity of Phenol-Rich Fraction of Piper sylvaticum Roots}, journal = {Pharmacognosy Research}, volume = {10}, year = {2018}, month = {October 2018}, pages = {339-342}, type = {Original Article}, chapter = {339}, abstract = {

Obective: Piper sylvaticum Roxb. is an important folk medicine in Indian Traditional System of Medicine widely used by different tribes in many countries. In the present study, the anticonvulsant activity of extract/fractions of Piper sylvaticum (PS) roots was investigated. Materials and Methods: 70\% ethanolic extract of PS roots was successively extracted using hexane and ethyl acetate to prepare various fractions. Total phenol content was found at maximum 324.65 mg/gallic acid equivalent/g in ethyl acetate fraction (EAF) (phenol-rich fraction [PRF]). High-performance thin-layer chromatography fingerprinting profiling of PS roots was performed. The anticonvulsant properties of the EAF of roots of PS were examined by maximal electroshock method as compared to standard phenytoin (25 mg/kg body weight). Result: It was found that EAF shows potent anticonvulsant activity at different dose levels against maximum electroshock seizure-induced convulsions in Swiss albino mice. Conclusion: From the observation, it can be concluded that the current study has expressed that the phenol-rich EAF of the ethanolic extract of the roots of PS has shown the dose-dependent anticonvulsant effect in mice. The anticonvulsant potential may be due to the presence of phenolic compounds in PRF. The outcomes suggested a high potential for application of EAF of PS root as an anticonvulsant agent.

}, keywords = {Anticonvulsant activity, High-performance thin-layer chromatography, Piper sylvaticum, Piperine}, doi = {10.4103/pr.pr_125_17}, author = {Akash Ved and Amresh Gupta and Om Prakash and Ajay Kumar Singh Rawat} } @article {875, title = {Antimicrobial Screening of Ethnobotanically Important Stem bark of Medicinal Plants}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {September 2010}, pages = {254-257}, type = {Original Article}, chapter = {254}, abstract = {

Background: The stem barks are the rich sources of tannins and other phenolic compounds. Tannins inhibited the growth of various fungi, yeast, bacteria and virus. Hence, ten stem barks of ethnomedicinally important plants were screened for antibacterial and antifungal activities against human pathogenic strains. Methods: Air-dried and powdered stem bark of each plant was extracted with 50\% aqueous ethanol, lyophilized and the dried crude extracts were used for the screening against 11 bacteria and 8 fungi. Antibacterial and antifungal activities were performed according to microdilution methods by NCCLS. Results: The plants Prosopis chilensis, Pithecellobium dulce, Mangifera indica showed significant antibacterial and antifungal activities against Streptococcus pneumonia, Enterobacter aerogenes, Klebsiella pneumonia and Candida albicans with MIC of 0.08mg/ml. Pithecellobium dulce bark also showed significant antibacterial activity against Bacillus cereus. Conclusion: The bark of Pithecellobium dulce has more or less similar activity against the known antibiotic and may be considered as potent antimicrobial agent for various infectious diseases.

}, keywords = {Antibacterial, Antifungal, Bark, Ethnobotany, MIC}, doi = {10.4103/0974-8490.69127}, author = {Meenakshi Singh and Sayyada Khatoon and Shweta Singh and Vivek Kumar and Ajay Kumar Singh Rawat and Shanta Mehrotra} }