@article {993, title = {In-silico Molecular Docking Studies of some Isolated Phytochemicals from Biophytum veldkampii against Cyclooxygenase-II Enzyme and in vivo Anti-inflammatory Activity}, journal = {Pharmacognosy Research}, volume = {13}, year = {2021}, month = {October 2021}, pages = {192-198}, type = {Original Article}, chapter = {192}, abstract = {

Background: The current study estimate the anti-inflammatory activity of whole plant of Biophytum veldkampii on carageenan induced inflammation on rats compiled by molecular docking studies of phytocompounds from the plants with Cyclooxygenase II (PDB ID: 3LN1). Methods: In this research Biophytum veldkampii was subjected to extraction using methanol. In-vivo anti-inflammatory activity was assessed by using carageenan induced inflammation on rats and in-silico molecular docking studies was performed by using of Autodock 4.0. Results: The outcomes revealed that the methanolic extract has most prominenant anti-inflammatory activity at various doses. Among all the substances 2,6,3{\textquoteright},4{\textquoteright}-Tetrahydroxy-2-benzylcoumaranone revealed the most effective docking rating of -6.8, which is near to Diclofenac, i.e. - 6.9, ensuring that 2,6,3{\textquoteright},4{\textquoteright}-Tetrahydroxy-2-benzylcoumaranone has a strong binding fondness in between protein and ligand. Conclusion: From the results, a conclusion can be drawn that the anti-inflammatory activity of Biophytum veldkampii in both in vivo and in silico methods. This information sustains 2,6,3{\textquoteright},4{\textquoteright}-Tetrahydroxy-2-benzylcoumaranone to be a useful anti-inflammatory compound beneficial to future clinical studies.

}, keywords = {2, 3{\textquoteright}, 4{\textquoteright}-Tetrahydroxy-2 benzylcoumaranone, 6, Autodock4.0, Carageenan, Cyclooxygenase II, In-silico, Inflammation, Phytochemical}, doi = {10.5530/pres.13.4.11}, author = {Nagaraju Bandaru and D.S.N.B.K Prasanth and A.Rajasekhar Reddy and G.S.N Koteswara Rao and Kumar V.S Nemmani and Alla Narayana Rao} }