@article {949, title = {Modulating Effect of Gmelina arborea Linn. on Immunosuppressed Albino Rats}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {January 2011}, pages = {359-363}, type = {Original Article}, chapter = {359}, abstract = {

Aim: In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated. Materials and Methods: Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was evaluated on humoral and cell-mediated immune response using animal models like cyclophosphamide-induced myelosuppression, delayed-type hypersensitivity (DTH) response, and humoral antibody (HA) titre. Results: Both test extracts produced significant increase in HA titre, DTH response, and levels of total white blood cell count. Conclusion: This drug is found to be a potential immunostimulant.

}, keywords = {Cellular immunity, Gmelina arborea, Humoral immunity, Immunomodulation}, doi = {10.4103/0974-8490.75455}, author = {SH Shukla and AK Saluja and SS Pandya} }