@article {861, title = {Anti-leukemia Activity of Methanolic Extracts of Lantana camara}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {274-279}, type = {Original Article}, chapter = {274}, abstract = {

Anticancer effect of Lantana camara{\textquoteright}s root and leaf extracts against Jurkat leukemia cell line was investigated by MTT assay. These extracts had statistically similar antineoplastic property (root IC50, 328.36 {\textpm} 53.08 μg/ml; leaf, 394.41 {\textpm} 99.73 μg/ml; p \> 0.1, n = 3), averagely 1/10 times as activity as carboplatin (IC50 34.83 {\textpm} 3.60 μg/ml; p \< 0.05, n = 3). Decreasing cytotoxicity at higher concentrations implied the existence of cytoprotective compounds. Morphological examinations indicated apoptosis induction as the mechanism of activity on Jurkat cells. In conclusion, L. camara{\textquoteright}s root and leaf extracts might be subjects for further fractionation and identification to find new anticancer agents.

}, keywords = {anticancer, Cell Culture, Jurkat Cell Line, Lantana camara, MTT assay}, doi = {Nil}, author = {Badakhshan Mahdi Pour and Sreenivasan Sasidharan and Rameshwar Naidu Jegathambigai and Ramanathan Surash} }