@article {736, title = {Solanum Trilobatum in the Management of Atopy: Through Inhibition of Mast Cell Degranulation and Moderation of Release of Interleukins}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {March 2010}, pages = {10-14}, type = {Original Article}, chapter = {10}, abstract = {

Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1α and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats.

}, keywords = {Histamine, Immunomodulation, Interleukin, Mast cell, Medicinal plants, Solanum trilobatum}, doi = {10.4103/0974-8490.60581}, author = {MS Ranjith and A J A Ranjitsingh and S Gokul Shankar and GS Vijayalaksmi and K Deepa and K Babu and Harcharan Singh Sidhu} }