@article {545, title = {Antioxidant and Antiacetylcholinesterase Activity of Teucrium Hyrcanicum,}, journal = {Pharmacognosy Research}, volume = {7}, year = {2015}, month = {June 2015}, pages = {s15-s19}, type = {Original Article }, chapter = {s15}, abstract = {

Background:Teucrium hyrcanicum\ belonging to the Lamiaceae family is a native plant in Iran; it is called Maryam nokhodi-e-jangali in Farsi.\ Objective:\ The aim of this study is to evaluate acetylcholinesterase inhibition (AChEI), antioxidant activity and flavonoids content of\ T.hyrcanicum\ methanol extract.\ MaterialsandMethods:\ The air-dried and the ground aerial parts of\ T. hyrcanicum\ were extracted by percolation method with methanol. Antioxidant activity of the extract was investigated by using 2,2{\textquoteright}-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power assay (FRAP) methods. In addition, AChEI and flavonoid content of\ T. hyrcanicum\ methanol extract were measured.\ Results:\ The results showed that total flavonoid content of\ T. hyrcanicum\ in reference to the standard curve for quercetin was 20.70 {\textpm} 0.05 mg quercetin equivalents/g of extract. In the FRAP method, the antioxidant activity of\ T. hyrcanicum\ extract and butyl hydroxyanisole (BHA) (as a positive control) were 657.5 {\textpm} 0.04 and 880 {\textpm} 0.06 mmol Fe II/1 g dried extract. According to results of DPPH assay, half maximal inhibitory concentration (IC50\ ) value for DPPH radical-scavenging activities of\ T. hyrcanicum\ methanol extract, vitamin E and BHA were 74.6, 14.12 and 7.8 μg/mL, respectively. IC\ 50\ value for AChEI of\ T. hyrcanicum\ and donepezil as a positive control were 2.12 mg/mL and 0.013 mg/mL.\ Conclusion:\ The results of the present study showed\ T. hyrcanicum\ is a natural antioxidant that the flavonoid content can be responsible for extract effects.

}, keywords = {Aantioxidant Activity, Acetylcholinesterase Inhibitory, Flavonoid Contents, Teucrium Hyrcanicum}, doi = {10.4103/0974-8490.157993 }, author = {Fereshteh Golfakhrabadi and Fatemeh Yousefbeyk and Tahmineh Mirnezami and Pedram Laghaei and Mannan Hajimahmoodi and Mahnaz Khanavi} }