@article {502,
	title = {Croton grewioides Baill. (Euphorbiaceae) Shows Antidiarrheal Activity in Mice},
	journal = {Pharmacognosy Research},
	volume = {8},
	year = {2016},
	month = {May 2016},
	pages = {202-205},
	type = {Short Communication},
	chapter = {202},
	abstract = {<p class="rtejustify">Based on chemotaxonomy, we decided to investigate the possible antidiarrheal activity in mice of a crude ethanolic extract obtained from aerial parts of Croton grewioides (CG-EtOH). We tested for any possible toxicity in rat erythrocytes and acute toxicity in mice. Antidiarrheal activity was assessed by determining the effect of CG-EtOH on defecation frequency, liquid stool, intestinal motility and intestinal fluid accumulation. CG-EtOH showed no in vitro cytotoxicity and was not orally lethal. In contrast, the extract given intraperitoneally (at 2000 mg/kg) was lethal, but only in females. CG-EtOH produced a significant and equipotent antidiarrheal activity, both in defecation frequency (ED50 = 106.0 {\textpm} 8.1 mg/kg) and liquid stools (ED50 = 105.0 {\textpm} 9.2 mg/kg). However, CG-EtOH (125 mg/kg) decreased intestinal motility by only 22.7\% {\textpm}4.4\%. Moreover, extract markedly inhibited the castor oil-induced intestinal contents (ED50 = 34.6 {\textpm} 5.4 mg/ kg). We thus conclude that CG-EtOH is not orally lethal and contains active principles with antidiarrheal activity, and this effect seems to involve mostly changes in intestinal secretion.</p>
},
	keywords = {Croton grewioides, Diarrheal, Intestinal fluid, Motility, Toxicity},
	doi = {10.4103/0974-8490.181465},
	author = {Anne Dayse Soares da Silva and Karoline de Melo e Silva and Jos{\'e} Clementino Neto and Vicente Carlos de Oliveira Costa and Hilzeth de Luna F. Pess{\^o}a and Josean Fechine Tavares and Marcelo Sobral da Silva and Fabiana de Andrade Cavalcante}
}
