@article {211, title = {Antihypertensive Effect of Methanol Leaf Extract of Azadirachta indica is Mediated through Suppression of Renal Caspase 3 Expressions on Nω-Nitro-L-Arginine Methyl Ester Induced Hypertension}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {January 2021}, pages = {460-465}, type = {Original Article}, chapter = {460}, abstract = {

Background: Azadirachta indica (AI) Adr Juss (Meliaceae), known as neem, has been used traditionally for the treatment of various disease conditions including obesity and hypertension. Objective: The antihypertensive effect and mechanism of action of modulatory effect of AI were investigated after the induction of hypertension using Nω-nitro-L-arginine methyl ester (L-NAME). Materials and Methods: Five groups of ten rats divided as follows: Control; L-NAME (40 mg/kg); L-NAME + 100 mg/kg AI; L-NAME and 200 mg/kg AI; and L-NAME and Enalapril (25 mg/kg) were used. Results: following the application of L-NAME, hypertension (elevated systolic, diastolic, mean arterial blood pressures) and increased levels of oxidative stress markers were observed in rats. Immunohistochemistry showed increased caspase-3 expressions in hypertensive rats compared to normotensive rats. Conversely, AI treatment resulted in restoration of physiological antioxidant status and normotension, comparable to the standard antihypertensive agent enalapril. Conclusion: AI leaf is a good candidate for the management of high blood pressure.

}, keywords = {Antioxidant, Apoptosis, Azadirachta indica, Hypertension, Oxidative stress, Phytotherapy}, doi = {10.4103/pr.pr_10_20}, author = {Temidayo Olutayo Omobowale and Ademola Adetokunbo Oyagbemi and Olumuyiwa Abiola Adejumobi and Fisayo Ugbor and Ebunoluwa Racheal Asenuga and Temitayo Olabisi Ajibade and Jeremiah Moyinoluwa Afolabi and Blessing Seun Ogunpolu and Olufunke Olubunmi Falayi and Idayat Titilayo Gbadamos and Olufunke Eunice Ola-Davies and Adebowale Bernard Saba and Anofi Ashafa and Momoh Audu Yakubu and Adeolu Alex Adedapo and Oluwafemi Omoniyi Oguntibeju} }