Aim: In this study, we performed a bibliometric analysis focusing on the general patterns of scientific publications about Calotropis, bibliometric analysis of Calotropis research carried out globally from 2011 to 2020. Materials and Methods: The analysis is based on 6,584 research articles identified using the Scopus database tool, further Bibliometric tools such as Biblioshiny and VOSviewer have been used to perform bibliometric analysis and build data matrixes for co-citation, coupling, scientific collaboration analysis, and co-word analysis. Results: The results show that there is an increase in the number of articles, particularly from countries like India and China. Ramos, Márcio Viana and Rahmatullah, Mohammed are identified as the most influential authors, and King Saud University, Saudi Arabia and Universidade Federal do Ceara, Brazil as key organisations. “Methods for in vitro evaluating antimicrobial activity: A review” this paper total of 1679 citations are received. Total of 105 articles published during this period are highly cited. Journal of Ethnopharmacology and International Journal of Pharmacy and Pharmaceutical Sciences are the important journals identified. The most common area of the research focus has been on the most common area of the research focus has been on the Agricultural and Biological Sciences, Pharmacology, Toxicology and Pharmaceutics, Biochemistry, Genetics, and Molecular Biology and Medicine. Findings: Our findings can act as a useful reference for researchers, and provide insights for directing future research on Calotropis that has potential implications for forming across the world.