Phytochemical and Pharmacological Screening of Begonia grandis Dryand

Srinivasarao Pendy; Krishna Nallamothu; Ganapaty Seru; Sunitha Katta; Sumanta Mondal

Phytochemical and Pharmacological Screening of Begonia grandis Dryand

Articles

Abstract

Pharmacognosy Research,2020,12,4,375-379.

DOI:10.4103/pr.pr_67_20

Published:January 2021

Type:Original Article

Authors:

Author(s) affiliations:

Srinivasarao Pendy¹, Krishna Nallamothu¹, Ganapaty Seru², Sunitha Katta², Sumanta Mondal²

¹Research and Development Wing, Divis Laboratories Ltd, Visakhapatnam, Andhra Pradesh, INDIA.

²GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, INDIA.

Abstract:

Begonia grandis Dryand (Family: Begoniaceae) was screened for its phytoconstituents and evaluated for its ethnomedicinal potential as an antioxidant and hepatoprotective agent. The preliminary phytochemical studies of the B. grandis revealed the presence of alkaloids, flavonoids, glycosides, triterpenoids, and steroids. Antioxidant effect of the methanolic extract was assessed by DPPH, superoxide, hydroxyl radical scavenging activity, and hepatoprotective effect by CCl₄-induced hepatotoxicity. The extract showed significant antioxidant and hepatoprotective effects at a dose of 400 mg/kg similar to that observed in ascorbic acid and silymarin.

Keywords:Antioxidant, Begonia grandis, Begoniaceae, Ethnomedicinal, Hepatoprotective, Silymarin