Thermogenic Blend Alone or in Combination with Whey Protein Supplement Stimulates Fat Metabolism and Improves Body Composition in Mice

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Abstract
Pharmacognosy Research,2018,10,1,37-43.
Published:February 2018
Type:Original Article
Authors:
Author(s) affiliations:

Paula de Lima Vieira-Brock, Brent M Vaughan, David L Vollmer

Research and Development, 4Life Holdings, LLC, Sandy, Utah 84070, USA.

Abstract:

Background: Certain food ingredients promote thermogenesis and fat loss. Similarly, whey protein improves body composition. Due to this potential synergistic effect, a blend of thermogenic food ingredients containing African mango, citrus fruit extract, Coleus forskohlii, dihydrocapsiate, and red pepper was tested alone and in combination with a whey protein supplement for its effects on body composition in sedentary mice during high‑fat diet. Objective: The objective of this study was to evaluate the interaction of thermogenic foods on improving body composition during consumption of an unhealthy diet. Materials and Methods: C57BL/6J young adult male mice (n = 12) were placed on a 60% high‑fat diet for 4 weeks and subsequently randomly assigned to receive daily dosing by oral gavage of vehicle, the novel blend alone or with whey protein supplement for another 4 weeks. Body composition, thermal imaging of brown adipose tissue (BAT), mitochondrial BAT uncoupling protein 1 (UCP1), and plasma levels of leptin were assessed. Results: Novel blend alone and in combination with protein supplement attenuated body weight gain, fat, and increased surface BAT temperature in comparison to vehicle control and to baseline (P < 0.5). The combination of novel blend and whey protein supplement also significantly increased UCP1 protein expression in BAT mitochondria in comparison to vehicle control and novel blend alone (P < 0.5). Conclusions: These data indicate that this novel blend stimulates thermogenesis and attenuates the gain in body weight and fat in response to high‑fat diet in mice and these effects were improved when administered in combination with whey protein supplement.

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The novel blend alone or in combination with whey protein supplement attenuated body weight gain during high‑fat diet. Data are expressed as mean values ± standard error of the mean (a) body weight at baseline and the last day of the study and (b) body weight change over time. Within‑group comparison: *Indicate values significantly different from baseline (P < 0.05). Between‑group comparison: groups that do not share a common letter are statistically different (P < 0.05)

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