Ameliorative Effect of Curcumin on Olanzapine‑induced Obesity in Sprague‑Dawley Rats

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Abstract
Pharmacognosy Research,2017,9,3,247-252.
Published:July 2017
Type:Original Article
Authors:
Author(s) affiliations:

Subramani Parasuraman1, Khor Ming Zhen1, Urmila Banik2, Parayil Varghese Christapher1

1Unit of Pharmacology, Faculty of Pharmacy, AIMST University, Kedah, MALAYSIA.

2Department of Pathology, Faculty of Medicine, AIMST University, Kedah, MALAYSIA.

Abstract:

Objective: To evaluate the effect of curcumin on olanzapine‑induced obesity in rats. Materials and Methods: Sprague‑Dawley (SD) rats were used for experiments. The animals were divided into six groups, namely, normal control, olanzapine control, betahistine (10 mg/kg), and curcumin 50, 100, and 200 mg/kg treated groups. Except the normal control group, all other animals were administered with olanzapine 4 mg/kg intraperitoneally to induce obesity. The drugs were administered once daily, per oral for 28 days. During the experiment, body weight changes and behavior alterations were monitored at regular intervals. At the end of the experiment, blood sample was collected from all the experimental animals for biochemical analysis. Part of the liver and kidney tissues was harvested from the sacrificed animals and preserved in neutral formalin for histopathological studies. Results: Curcumin showed a significant reduction in olanzapine‑induced body weight gain on the rats and improved the locomotor effects. The effect of curcumin on olanzapine‑induced body weight gain is not comparable with that of betahistine. Conclusion: This study has shown metabolic alteration effect of curcumin on olanzapine, an antipsychotic drug, treated SD rats.

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Percentage changes in body weight alterations of experimental animals. All the values are mean ± standard error of the mean (n = 6)

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