Flavonoid Glycosides and Pharmacological Activity of Amphilophium Paniculatum

Articles

Abstract
Pharmacognosy Research,2013,5,1,17-21.
Published:January 2013
Type:Original Article
Authors:
Author(s) affiliations:

Mahmoud I Nassar1, El-Sayed A Aboutabl2, Dina M Eskander1, Mary H Grace1, Ezzel-Din A EL-Khrisy1, Amany A Sleem3


1Department of Chemistry of Natural Compounds, National Research Centre, Dokki, Egypt
2Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Dokki, Cairo, Egypt
3Department of Pharmacognosy, National Research Centre, Dokki, Cairo, Egypt

Abstract:

Background: Nothing is reported on Amphilophium paniculatum (L.) Kunth. This study aimed at investigation of chemical constituents of the leaves of Amphilophium paniculatum, grown in Egypt, in addition to pharmacological evaluation. Materials and Methods: Isolation of a new compound, along with 5 known flavonoids. Pharmacological activities were carried out on different extracts of A. paniculatum leaves. Results: Identification of a new flavone glycoside, acacetin 8-C-β-D- glucopyranosy l-(1→2)-α-L-rhamnopyranoside (1) in addition to 5 known flavonoids. The 70% ethanol crud extract and its successive chloroform, ethyl acetate, and 100% ethanol extracts showed significant anti-inflammatoryactivity,analgesic effect, antipyretic activity, antioxidant activity, and anti-hyperglycemic activity. Determination of the median lethal dose (LD 50 ) revealed that the different extracts were safe.

PDF
Current View
Click here to download the PDF file.
Images

Structure of compound 1

Keywords