Chemical Constituents and Biological Studies of Origanum vulgare Linn.

Gottumukkala Venkateswara Rao; T. Mukhopadhyay; T. Annamalai; N. Radhakrishnan; M. R. Sahoo

Chemical Constituents and Biological Studies of Origanum vulgare Linn.

Articles

Abstract

Pharmacognosy Research,2011,3,2,143-145.

DOI:10.4103/0974-8490.81964

Published:June 2011

Type:Short Communication

Authors:

Author(s) affiliations:

Gottumukkala Venkateswara Rao, T. Mukhopadhyay, T. Annamalai, N. Radhakrishnan, M. R. Sahoo

CavinKare Research Centre, Ekkattuthangal, Chennai – 600 032, India.

Abstract:

Bioassay-guided isolation of methanolic extract of the leaves of Origanum vulgare Linn., yielded two protocatechuic acid ester derivatives, origanol A (1) and origanol B (2) along with ursolic acid (3), oleanolic acid (4), β-sitosterol (5), and triacontanol (6). Structures of the compound were established based on physical and spectral data (UV, IR, 1H and 13C NMR and mass). Origanol A (1) showed significant mushroom tyrosinase inhibition activity.

Keywords:Origanol A and B, Origanum vulgare Linn., Triterpene acids, Tyrosinase inhibition, β-sitosterol