ArticlesAbstractPharmacognosy Research,2010,2,3,181-185.DOI:10.4103/0974-8490.65514Published:July 2010Type:Original ArticleAuthors:Azadeh Sabetghadam, Surash Ramanathan, and Sharif Mahsufi Mansor Author(s) affiliations:Azadeh Sabetghadam, Surash Ramanathan, Sharif Mahsufi Mansor Centre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia Abstract:Mitragyna speciosa Korth is a medicinal plant indigenous to Thailand and Malaysia and has been known for its narcotic and coca-like effects. Many studies have been performed on the antinociceptive effect of the plant extracts of Thai origin; however, limited studies have been reported till date on M. speciosa extracts of Malaysian origin. Various concentrations of alkaloid (5–20 mg/kg), methanolic (50–200 mg/kg), and aqueous (100–400 mg/kg) extracts of Malaysian M. speciosa leaves were prepared and orally administered to nine groups of rats. Morphine (5 mg/kg, s.c.) and aspirin (300 mg/kg, p.o.) were used as control. Antagonism of the antinociceptive activity was evaluated by pretreatment with naloxone at a dose of 2 mg/kg (i.p.). Results showed that oral administration of the alkaloid (20 mg/kg), methanolic (200 mg/kg), and aqueous (400 mg/kg) extracts significantly prolonged the latency of nociceptive response compared with control groups in both hot plate and tail flick tests (P < 0.05). Antinociceptive action of the alkaloid (20 mg/kg), methanolic (200 mg/ kg), and aqueous (400 mg/kg) extracts was significantly blocked by naloxone. In conclusion, these results suggest the presence of antinociceptive effect in various extracts of Malaysian M. speciosa leaves. In addition, the antinociceptive effective doses vary depending on the type of solvents used for extraction. Keywords:Alkaloid, Antinociceptive, Aqueous, Extract, Methanol, Mitragyna speciosaView:PDF (734.16 KB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images The Evaluation of Antinociceptive Activity of Alkaloid, Methanolic, and Aqueous extracts of Malaysian Mitragyna speciosa Korth leaves in rats KeywordsAlkaloidAntinociceptiveAqueousExtractMethanolMitragyna speciosa ‹ Senna occidentalis Leaf Extract Possesses Antitrypanosomal Activity and Ameliorates the Trypanosome-induced Anemia and Organ Damage up A New Alkaloid Isolated from Abies webbiana Leaf ›