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Year : 2021  |  Volume : 13  |  Issue : 1  |  Page : 28-33

Antiarthritic and antinociceptive potential of ethanolic extract from leaves of Doliocarpus dentatus (aubl.) standl. in mouse model

1 Health Sciences, Federal University of Grande Dourados, Dourados, Brazil
2 Faculty of Exact Sciences and Technology, Postgraduate Program in Chemistry, Federal University of Grande Dourados, Dourados, Brazil
3 Faculty of Pharmaceutical Sciences, Federal University of Mato Grosso do Sul, Campo Grande, Brazil
4 Faculty of Medicine (FAMED) “Dr. Helio Mandetta”, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil
5 Center of Studies in Natural Resources, State University of Mato Grosso do Sul, Dourados, Brazil
6 Department of Morphology, Institute of Biosciences of Botucatu, Paulista State University, Botucatu, SP, Brazil

Correspondence Address:
Dr. Maria Helena Verdan
Federal University of Grande Dourados, Rodovia Dourados/Itahum, Km 12, Mailbox 364, Postal Code: 79804-970, Dourados, Mato Grosso do Sul
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pr.pr_79_20

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Objectives: The folk use of Doliocarpus dentatus for pain and inflammatory conditions led our group to evaluate the anti-inflammatory, antinociceptive, and antiarthritic effects of its ethanol extract from the leaves (EEDd) on mouse models. Results: Oral treatments with EEDd (100–300 mg/kg) significantly inhibited the formalin-induced nociceptive and cold sensitivity, prevented acetic acid-induced nociceptive behavior, and prevented articular inflammation (including knee edema, leukocyte infiltration, and mechanical hyperalgesia) induced by zymosan. In the peritonitis model, betulinic acid (BA, 0.3–30 mg/kg) and EEDd (300 mg/kg) significantly inhibited zymosan-induced leukocyte infiltration. In the complete Freund adjuvant (CFA) model, oral treatments with EEDd (100–300 mg/kg) for 21 days significantly inhibited mechanical hyperalgesia, cold response, and edema. In the MTT viability assay, EEDd (3–90 μg/mL) did not induce leukocytes cytotoxicity. cytotoxicity. Most models employed male and female Swiss mice or, for the CFA test, C57BL/6 mice. Conclusion: This study demonstrates that EEDd exhibited antinociceptive, antihyperalgesic, and antiarthritic potential in mice and BA contribute for the EEDd observed activities.

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