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ORIGINAL ARTICLE
Year : 2020  |  Volume : 12  |  Issue : 4  |  Page : 444-449

Acute toxicity and cytogenotoxicity of yangambin isolated from Ocotea duckei vattimo-gil


1 Postgraduate Program in Morphotechnology - Federal University of Pernambuco, João Pessoa, PB, Brazil
2 Postgraduate Program in Morphotechnology - Federal University of Pernambuco; Department of Histology and Embryology-Federal University of Pernambuco, João Pessoa, PB, Brazil
3 Multiprofessional Residency Program in Health Surveillance - Recife Health Department, João Pessoa, PB, Brazil
4 Institute of Drugs and Medicines Research - Federal University of Paraíba, 58051 900, João Pessoa, PB, Brazil

Correspondence Address:
Prof. Maria Isabel de Assis Lima Castro
Av. Prof. Moraes Rego, s/n, Cidade Universitaria (ala sul do predio de Medicina). CEP: 50.760 420
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pr.pr_73_20

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Background: Yangambin, a lignan isolated from Ocotea duckei leaves, has been reported to have antitumor, anxiolytic, hypotensive, and leishmanicidal activity, but there is little information on toxicity. Objective: The aim of this study was to investigate the acute toxicity of yangambin in mice, and cytotoxicity and genotoxicity through the Allium cepa assay. Materials and Methods: The yanganbin at a dose of 2000 mg/kg was orally administered once to mice to investigate acute toxicity, and meristem of the roots of Allium cepa was used to determine inhibition of root growth (root length) and mitotic index. Results: Yangambin did not cause hemolysis in sheep erythrocytes at concentrations of 12.5, 25, and 50 μg/mL, and did not show genotoxic changes in root meristem cells of Allium cepa at the same concentrations. In the acute toxicity study in Swiss mice at a dose of 2000 mg/kg, there were no apparent clinical signs or any behavioral changes and no deaths. Conclusion: Therefore, yangambin appears to a promising active compound for future pharmacological studies.


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