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Year : 2020  |  Volume : 12  |  Issue : 4  |  Page : 375-379

Phytochemical and Pharmacological Screening of Begonia grandis Dryand

1 Research and Development Wing, Divis Laboratories Ltd, Visakhapatnam, Andhra Pradesh, India
2 GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India

Correspondence Address:
Prof. Ganapaty Seru
GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pr.pr_67_20

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Begonia grandis Dryand (Family: Begoniaceae) was screened for its phytoconstituents and evaluated for its ethnomedicinal potential as an antioxidant and hepatoprotective agent. The preliminary phytochemical studies of the B. grandis revealed the presence of alkaloids, flavonoids, glycosides, triterpenoids, and steroids. Antioxidant effect of the methanolic extract was assessed by DPPH, superoxide, hydroxyl radical scavenging activity, and hepatoprotective effect by CCl4-induced hepatotoxicity. The extract showed significant antioxidant and hepatoprotective effects at a dose of 400 mg/kg similar to that observed in ascorbic acid and silymarin.

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