| ORIGINAL ARTICLE |
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| Year : 2019 | Volume
: 11
| Issue : 4 | Page : 389-395 |
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Antilipidemic properties of Calpurnia aurea leaf extract on high-fat diet induced hyperlipidemia
Welde Mengistu1, Seifu Daniel2, Natesan Gnanasekaran2
1 Department of Biomedical Sciences, Biomedical Sciences Unit, College of Health Sciences, Jimma University, Jimma, Ethiopia
2 Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
Correspondence Address:
Dr. Natesan Gnanasekaran
Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa
Ethiopia
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/pr.pr_10_18
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Background: Hyperlipidemia is described by raised in the plasma lipids including triglycerides (TG), cholesterols, cholesterol esters, phospholipids as well as plasma lipoproteins, for example, very low-density lipoprotein (LDL), LDL, and reduction in the circling high-density lipoprotein (HDL) levels. Objective: To explore the antilipidemic properties of the hydromethanolic extract of Calpurnia aurea (HMECA) leafs against high-fat diet-induced hyperlipidemic male albino Wistar rats. Materials and Methods: Thirty albino Wistar rats of 60–75 days and weights of 150–200 g were isolated arbitrarily into six groups of five each. Group I fed with normal diet in as typical control, Group II got high-fat-eating routine (48.8% fat w/w) containing fat produced using hamburger fat and blended with hydrogenated vegetable oil, Group III fed with high fat diet plus 3.5 mg/kg/day atorvastatin as standard control, and the remaining Groups IV, V, and VI fed with high fat diet along with different does of HMECA at 200, 300, and 400 mg/kg/day separately for 60 days. Food intake, body weight, body mass index, serum lipid profiles, and liver histopathology were studied. Results: The results of this investigation exposed that HMECA has dose-dependent antilipidemic exercises. HMECA treatment of 400 mg/kg caused a noteworthy bringing down of P < 0.05 of serum LDL from 28.53 ± 12.2 mg/dl to 9.70 ± 5.77 mg/dL; the serum cholesterol level from 92.00 ± 13.0 mg/dl to 60.33 ± 8.60 mg/dl; the serum TG leve1 from 84.73 ± 19.4 mg/dl to 71.83 ± 13.0 mg/dl mg/dl; and increased the serum HDL-cholesterol levels from 11.66 ± 1.23 mg/dl to 29.66 ± 1.52 mg/dl. At the medium dosage of 300 mg/kg, it was not successful as 400 mg/kg and at the insignificant dosage of 200 mg/kg brought numerical contrast not statistically noteworthy among the serum lipid profile. Conclusion: This research discovered that the HMECA possesses a significant antilipidimic activity in dose dependent manner. The molecular mechanism of antilipidemic exercises of this medication should be contemplated.
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