Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
Advanced search 
Year : 2018  |  Volume : 10  |  Issue : 3  |  Page : 319-324

In vitro investigation effects of 4-Hydroxyacetophenone on rat thoracic aorta's vasomotor activity

1 Department of Physiology, Faculty of Veterinary, Kafkas University, Kars, Turkey
2 Department of Physiology, Faculty of Veterinary, Atatürk University, Erzurum, Turkey

Correspondence Address:
Dr. Volkan Gelen
Department of Physiology, Faculty of Veterinary, Kafkas University, Kars
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pr.pr_11_18

Rights and Permissions

Background: Z. clinopodioides Lam. is also known as a ''Field Mint'' Seven compounds which have vasodilator activity have been isolated from Z. clinopodioides Lam. and two of them are phenolics compounds and these are acetovanillone, 4-HAP, four of them are flavonoids and these are acacetin, apigenin, chrysin, thymonin, one derivat of cinnamic acid and ethyl 4-coumarate. Objective: In this study, it was aimed that was defined vasodilator activiy mechanisms of fenolic compound 4-HAP on isolated rat thorasic aorta. Material and Method: In this study 40 male adult Sprague Dawley rats were used. Prepared rings were laid out into the 20 ml organ bath with Krebs solution. Rings were stretched by 1g and they were subjected to 1 hour incubation period. In the end of the incubation period, PE, KCI, nifedipine, L-NAME, 4-HAP, SQ22.536, ODQ, ACh, SKF96365, Propranolol, Atropin, TEA, Gibenclamide, 4-aminopyridine and U73122 were implemented to bath with a protocol. Results: Mechanisms of relaxed effect the of 4-HAP were assigned by using antagonists. It was observed that vasorelaksan effect of 4-HAP on endothelilal aorta smooth muscle contractions which had been inductioned by PE under the existance of L-NAME was considerably inhibited. Conclusion: It was stated that 4-HAP relaxed PE and KCI contractions and owing to this activity endothel intact tissues on L-NAME existance notably decreased because of NO pathyway. It is firmly believed that as relaxed effect of 4-HAP declines remarkably under the existance of 4-aminopyridine and nifedipine on endothel denuded aorta rings, activity could be on K+ channel and L-type Ca+2 channel. Abbreviations Used: 4-HAP: 4-hydroxyacetophenone, SQ22536: 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine, 9-THF-Ade, L-NAME: N (omega)-nitro-L-arginine methyl ester, DMSO: Dimethyl sulfoxide, 4-AP: 4-aminopyridine, TEA: Tetraethylammonium, ODQ: 1H-(1,2,4) oxadiazolo(4,3-a)quinoxalin-1-one, SKF96365: 1-[β-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenethyl] 1H-imidazolehydrochloride, 1-[2-(4-Methoxyphenyl)-2-[3-propoxy]ethyl]imidazole, U73122: 1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1H-pyrrole-2,5-dione, ACh: Acetylcholine, KCI: Potassium chloride, IP3: Inositol triphosphate, DAG: Diacylglycerol.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded104    
    Comments [Add]    

Recommend this journal