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Year : 2018  |  Volume : 10  |  Issue : 1  |  Page : 113-117

Comparative Molluscicidal and Schistosomicidal Potentiality of Two Solanum Species and Its Isolated Glycoalkaloids

1 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
2 Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt
3 Institute for Biomolecular Research, , Faculty of Chemistry and Biology, Hochschule Fresenius University of Applied Sciences, 65510 Idstein, Germany

Correspondence Address:
Dr. Muhammad A Alsherbiny
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., P. O. Box 11562, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pr.pr_71_17

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Schistosomiasis is the most noteworthy parasitic disease after malaria. Furthermore, the significant activity of the genus Solanum against Schistosoma worms and its intermediate host snails reinforced the study of Solanum seaforthianum Andr. (SS) and Solanum macrocarpon L. (SM) for their molluscicidal and schistosomicidal potentiality. In this study, different extracts, fractions and isolated compounds of both Solanum species are evaluated for the molluscicidal and schistosomicidal potentialities. The niclosamide was used as positive molluscicide control against Biomphalaria alexandrina snails. Different extracts, fractions, or isolated compounds were used at a concentration of 100 μg/ml and dead snails were counted in each case. On the other hand, washed and sterilized Schistosoma mansoni adult worms were used in three replicates, and three worm pairs were placed in each well with 2 ml test solution of 100 μg/ml concentration. Positive (praziquantel [PZQ] 0.2 ug/ml) and negative controls were concurrently used and examined daily for 3 days for viability. The mortality rate was calculated and then both LC50and LC90were determined in triplicates. Highest potency was indicated to total glycoalkaloid (TGA) fraction of SM followed by TGA of SS. On the other hand, TGA fractions of both species showed higher potency than other extracts and isolated compounds. Meanwhile, solasodine-free aglycone showed declined activity compared to its glycosides. Promising molluscicidal and schistosomicidal activities were displayed which are attributed to the glycoalkaloid content. Therefore, this study can efficiently contribute toward validation of the traditional use of SS and SM in schistosomiasis control.

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