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Year : 2017  |  Volume : 9  |  Issue : 2  |  Page : 168-173

Potential roles of Kleinhovia hospita L. leaf extract in reducing doxorubicin acute hepatic, cardiac and renal toxicities in rats

1 Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia
2 Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
3 Laboratory of Microbiology, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia
4 Laboratory Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia

Correspondence Address:
Yulia Yusrini Djabir
Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Jl. Perintis Kemerdekaan, KM.10, Tamalanrea 90245, Makassar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pr.pr_129_16

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Background: Doxorubicin (DOX) is a potent chemotherapy agent; however, its use may lead to cardiac, hepatic, and renal dysfunction. Kleinhovia hospita L extract contains antioxidant compounds that have been shown to reduce chemical-induced hepatotoxicity. Objectives: This study aimed to examine the protective effects of Kleinhovia sp. extract to reduce DOX acute toxicities. Materials and Methods: Thirty male rats were assigned to the following groups: Group I as controls, Group II was given DOX i.p. injection (25 mg/kg); Groups III, IV, and V were treated with Kleinhovia sp. extract 100, 250, and 500 mg/kg orally for 5 days, respectively, prior to DOX i.p. injection. After 24 h, blood and organs were analyzed for biomarker levels and histopathological changes. Results: DOX treatment in Group II significantly increased creatine kinase-MB (CK-MB), aspartate transaminase (AST), alanine transaminase (ALT), and urea levels compared to controls. Kleinhovia sp. extract at any given dose significantly improved ALT and AST; yet, CK-MB levels only reduced with 250 mg/kg dose (Group IV). Urea and creatinine levels in Kleinhovia sp. groups were also lower compared to DOX-treated rats, but it was not significant. Histopathological analysis showed improved liver, heart, and renal tissue structures in Kleinhovia sp-treated rats, especially at higher doses. Conclusion: Kleinhovia sp. extract at any dose given protected the rats from liver toxicity, but only at dose 250 mg/kg reduced cardiac toxicity. Although renal biomarkers were insignificantly lower, renal architecture was improved with Kleinhovia sp. treatment.

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