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Year : 2015  |  Volume : 7  |  Issue : 4  |  Page : 363-366

A new Antimicrobial Prenylated Benzo-lactone from the Rhizome of Cissus cornifolia

1 Department of Pharmaceutical and Medicinal Chemistry, Zaria, Nigeria
2 Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria
3 Department of Pharmaceutical and Medicinal Chemistry, Usmanu Danfodio University, Sokoto, Nigeria
4 Directorate of research, Nigeria Institute of Leather and Science Technology, Zaria, Nigeria
5 Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria

Correspondence Address:
Nasir Tajuddeen
Department of Chemistry Ahmadu Bello University, Zaria
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Source of Support: The authors thank the National Medicinal Plants Board, (New Delhi) for financial support,, Conflict of Interest: None

DOI: 10.4103/0974-8490.159572

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Background: Medicinal plants remain one of the largest reservoirs of new bioactive compounds. In this study, a new prenylated benzo-lactone (4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one) was isolated from the acetone extracts of the rhizome of Cissus cornifolia. The antimicrobial activity of the compound was evaluated against some microorganisms including Staphylococcus aureus, Salmonella typhi, and Candida albicans. Materials and Methods: The acetone extracts of the rhizome of C. cornifolia was separated and purified by various chromatographic techniques. The structure of the isolated compound was characterized by analysis of spectral data including one and two-dimensional nuclear magnetic resonance. Results: The isolated compound was characterized as (4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one), it showed activity against 6 out of 10 tested clinical isolates of some microorganisms including S. aureus, S. typhi, and C. albicans. The inhibition zones ranged between 17 mm and 25 mm. The inhibition zones observed compare favorably with the positive control used. Conclusion: The compound could serve as a lead for the development of more potent antimicrobial agent. To the best of our knowledge, this is the first report of the isolation and characterization as well as antimicrobial screening of the compound.

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