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SHORT COMMUNICATION
Year : 2015  |  Volume : 7  |  Issue : 2  |  Page : 213-216

In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta


Department of Biology, Faculty of Sciences Ain Chock, Laboratory of Physiology and Molecular Genetics, Immunology Unit, University Hassan II, B.P. 5366, M‚arif, Casablanca, Morocco

Correspondence Address:
Mounia Oudghiri
Department of Biology, Faculty of Sciences Ain Chock, Laboratory of Physiology and Molecular Genetics, University Hassan II, BP 5366, M‚arif, Casablanca
Morocco
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.150510

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Background: The aerial parts of Thymelaea hirsuta (TH) are used as a decoction in the treatment of different pathologies in folk medicine in Morocco. Objective: The aqueous extracts were evaluated for its anti-inflammatory activity and in inhibition of adjuvant induction arthritis in male Wistar rats. Materials and Methods: The anti-inflammatory activity was carried out using carrageenan-induced rat paw edema model, and the antiarthritic activity was carried out using complete Freund's adjuvant-induced arthritis model. Results: The plant extract (500 mg/kg body weight) exhibited significant activity in acute inflammation produced 60% of inhibition after 4 h as compared with that of the standard anti-inflammatory drug, the diclofenac (100 mg/kg) which showed 40% of inhibition. In arthritis model, the extract produced 85% inhibition after 18 days when compared with the diclofenac (10 mg/kg; 72%). Conclusion: These results indicate that the aqueous extract of TH had an anti-inflammatory activity and inhibited the induction of adjuvant arthritis in male Wistar rats.


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