Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 4  |  Page : 345-349

Phytochemical screening and anti-inflammatory activity of Cnidoscolus quercifolius (Euphorbiaceae) in mice


1 Collegiate of Pharmaceutical Sciences, Center of Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco 56.304-205, Brazil
2 Department of Physiology, Federal University of Sergipe, 49.100-000, São Cristóvão, Sergipe, Brazil

Correspondence Address:
Jackson Roberto Guedes da Silva Almeida
Center of Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco 56.304 - 205
Brazil
Login to access the Email id

Source of Support: The authors are grateful to the Brazilian agencies CNPq, CAPES and FACEPE for financial support, Conflict of Interest: None


DOI: 10.4103/0974-8490.138290

Rights and Permissions

Background: Cnidoscolus quercifolius is a species popularly known as "favela" and "faveleira", and belonging to the Caatinga biome (semi-arid vegetation, Brazil), where is used in folk medicine as an anti-inflammatory. Objective: The aim was to evaluate the anti-inflammatory effect of the ethanolic extract from barks (Cqb-EtOH) and leaves (Cql-EtOH) of C. quercifolius in mice using experimental models of inflammation. Materials and Methods: The preliminary phytochemical analysis of the ethanolic extract was performed. The activity was evaluated by paw edema induced by carrageenan and leukocytes migration to the peritoneal cavity induced by carrageenan methods. Results: A preliminary analysis of Cqb-EtOH revealed that it contained coumarins, flavonoids, monoterpenes/diterpenes and naphthoquinones, while the Cql-EtOH showed positive reaction to coumarins, anthracene derivatives, flavonoids, lignans and triterpenes/steroids. Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited significantly (P < 0.01) the increase in the edema volume after administration of carrageenan. In the peritonitis test, acute pretreatment with Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited the leukocyte migration. Conclusions: It can be concluded that extracts from the barks and leaves of C. quercifolius have anti-inflammatory activity, which supports the popular use of this plant to treat inflammation. Thus, extracts has significant anti-inflammatory properties, which are related probably to inhibition of release of mediators of the inflammatory process.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2891    
    Printed69    
    Emailed1    
    PDF Downloaded30    
    Comments [Add]    
    Cited by others 3    

Recommend this journal