| ORIGINAL ARTICLE |
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| Year : 2014 | Volume
: 6
| Issue : 4 | Page : 320-325 |
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Ameliorative effect of Phytocee™ Cool against carbon tetrachloride-induced oxidative stress
Joshua Allan Joseph1, Usha Parackal Thachappully Ayyappan1, Suja Rani Sasidharan2, Sridhar Mutyala3, Krishnagouda Shankargouda Goudar3, Amit Agarwal3
1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala, India
2 Pookode, Wayanad, Kerala, India
3 Department of Pharmacology and Toxicology, R&D Centre, Natural Remedies, Bangalore, Karnataka, India
Correspondence Address:
Joshua Allan Joseph
Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur - 680 651, Kerala
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8490.138284
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Background: Antioxidants from natural sources have a major role in reversing the effects of oxidative stress and promoting health, growth and productivity in animals. Objective: This study was undertaken to investigate the possible antioxidant activity and hepatoprotective effects of Phytocee™ Cool on carbon tetrachloride (CCl 4 ) induced oxidative stress and liver damage in rats. Materials and Methods: Animals were pretreated with Phytocee™ Cool for 10 days and were challenged with CCl 4 (1:1 v/v) in olive oil on the 10 th day. After 24 h of CCl 4 administration blood was collected and markers of hepatocellular damage aspartate aminotransferase (AST), alanine aminotransferase (ALT) were evaluated. Rats were sacrificed and oxidative stress in liver was estimated using malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase. Results: CCl 4 caused a significant increase in serum AST, ALT, hepatic MDA and GSH levels, whereas the SOD and catalase activities were decreased. Phytocee™ Cool pretreatment attenuated the MDA, AST ALT levels and increased the activities of SOD and catalase. Conclusion: Phytocee™ Cool demonstrated antioxidant potential and hepatoprotective effects and plausibly be used in the amelioration of oxidative stress. |
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