Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 3  |  Page : 204-209

Anti-diarrhoeal investigation from aqueous extract of Cuminum cyminum Linn. Seed in Albino rats


1 Department of Pharmacology and Experimental Biology, Vedica College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh, India
2 Department of Pharmaceutical Chemistry, Sri Sivani College of Pharmacy, Srikakulam, Andhra Pradesh, India
3 Department of Pharmaceutical Chemistry, Jayamukhi Institute of Pharmaceutical Science, Warangal, Andhra Pradesh, India
4 Department of Pharmacognosy and Phytochemistry, Sri Satya Sai Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India
5 Department of Pharmacognosy and Phytochemistry, Vedica College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh, India

Correspondence Address:
Dr. Mohan Lal Kori
Department of Pharmacognosy and Phytochemistry, Vedica College of Pharmacy, Bhopal - 462 033, Madhya Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.132596

Rights and Permissions

Background: Cuminum cyminum Linn. (Umbelliferae), commonly known as Jeera. It is native from mediterranean region, but today widely cultivated in Asian countries. It has been reported to possess various medicinal properties and an important food ingredient. The seed of the plant are claimed for treatment of diarrhoea by various traditional practitioners. Objectives: Hence, the present investigation was undertaken to evaluate aq. extract of C. cyminum seeds (ACCS) against diarrhoea on albino rats. Materials and Methods : The animals were divided into five groups and the control group was applied with 2% acacia suspension, the standard group with loperamide (3 mg/kg) or atropine sulphate (5mg/kg) and three test groups administered orally with 100, 250 and 500 mg/kg of ACCS. The antidiarrhoeal effect was investigated by castor oil induce diarrhoea model, prostaglandin E 2 (PGE 2 ) induced enteropooling model, intestinal transit by charcoal meal test. Results: The ACCS showed significant (P < 0.001) inhibition in frequency of diarrhoea, defecation time delaying, secretion of intestinal fluid as well as intestinal propulsion as compared to control and the graded doses of tested extract followed dose dependent protection against diarrhoea. Conclusions: The study reveals that the ACCS is a potent antidiarrhoeal drug which supports the traditional claim.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5634    
    Printed130    
    Emailed1    
    PDF Downloaded65    
    Comments [Add]    
    Cited by others 2    

Recommend this journal