Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2013  |  Volume : 5  |  Issue : 4  |  Page : 306-308

Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation


Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, India

Correspondence Address:
H.N. Aswatha Ram
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka
India
Login to access the Email id

Source of Support: Department of pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Conflict of Interest: The author(s) declare that they have no competing interests


DOI: 10.4103/0974-8490.118824

Rights and Permissions

Background: Sitopaladi churna (SPC) is a popular polyherbal ayurvedic formulation used in the treatment of allergy and respiratory diseases. Objective: The present study was aimed to justify the classical use of antiallergic claim by performing the mast cell stabilizing activity of extracts of SPC. Materials and Methods: The protective effect of aqueous extract and methanolic extract - of SPC against compound 48/80-induced mast cell degranulation model was carried out. Results: Sitopaladi churna aqueous extract (SPCA) at the dose of 300 mg/kg and Sitopaladi churna methanolic extract (SPCM) at the doses of 150 and 300 mg/kg showed better protection of mast cell degranulation (65%-74%) and were comparable to the standard drug ketotifen (79%), when peritoneal mast cells were treated with compound 48/80. The protection against mast cell degranulation was significant (P < 0.0001). Conclusion: From the above results, it has been justified that SPC can be used to treat allergic disorders.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2523    
    Printed57    
    Emailed0    
    PDF Downloaded50    
    Comments [Add]    

Recommend this journal