| ORIGINAL ARTICLE |
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| Year : 2013 | Volume
: 5
| Issue : 4 | Page : 306-308 |
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Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation
Inder K Makhija, Chandrashekara S Shreedhara, H.N. Aswatha Ram
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, India
Correspondence Address:
H.N. Aswatha Ram
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka
India
 Source of Support: Department of pharmacognosy, Manipal College of
Pharmaceutical Sciences, Manipal University, Manipal, Conflict of Interest: The author(s) declare that they have no competing interests  | Check |
DOI: 10.4103/0974-8490.118824
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Background: Sitopaladi churna (SPC) is a popular polyherbal ayurvedic formulation used in the treatment of allergy and respiratory diseases. Objective: The present study was aimed to justify the classical use of antiallergic claim by performing the mast cell stabilizing activity of extracts of SPC. Materials and Methods: The protective effect of aqueous extract and methanolic extract - of SPC against compound 48/80-induced mast cell degranulation model was carried out. Results: Sitopaladi churna aqueous extract (SPCA) at the dose of 300 mg/kg and Sitopaladi churna methanolic extract (SPCM) at the doses of 150 and 300 mg/kg showed better protection of mast cell degranulation (65%-74%) and were comparable to the standard drug ketotifen (79%), when peritoneal mast cells were treated with compound 48/80. The protection against mast cell degranulation was significant (P < 0.0001). Conclusion: From the above results, it has been justified that SPC can be used to treat allergic disorders. |
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