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Year : 2012  |  Volume : 4  |  Issue : 4  |  Page : 203-207

Evaluation of the protective and ameliorative properties of Garcinia kola on histamine-induced bronchoconstriction in guinea pigs

1 Department of Anatomy, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria
2 Department of Pharmacology and Toxicology, School of Pharmacy, University of Benin, Benin City, Nigeria

Correspondence Address:
Raymond I Ozolua
Department of Pharmacology and Toxicology, University of Benin, Benin City-300001
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-8490.102262

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Background: Garcinia kola is popularly used in African traditional medicine for the relief of acute bronchoconstrictive episodes. Objective: In this study, we examined the anti-asthmatic and morphological effects of the ethanol extract of G. kola in animal model. Materials and Methods: Guinea pigs were sensitized with ovalbumin and then given doses of 200 or 400 mg/kg/day for 21 consecutive days. Theophylline (10 mg/kg/day) was used as a standard. At the end of the exposure, the animals were exposed to 0.2% histamine aerosol in a chamber. Lymphocyte count, bronchial histology and morphometry were done. Results: Compared with non-sensitized controls, 200 mg/kg/day dose of the extract significantly (P < 0.05) increased the time taken for onset of preconvulsive dyspnea while the dose of 400 mg/kg/day significantly (P < 0.01) reduced bronchial wall thickness. Lymphocytes counts were not significantly affected but the bronchi of extract-treated animals were histologically clearer of lesions visible in the sensitized. Conclusion: These protective and ameliorative properties lend credence to the use of G. kola in ethnomedicine.

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