| ORIGINAL ARTICLE |
|
| Year : 2012 | Volume
: 4
| Issue : 2 | Page : 73-79 |
|
|
Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model
Priyanga Ranasinghe1, Sanja Perera1, Mangala Gunatilake2, Eranga Abeywardene1, Nuwan Gunapala1, Sirimal Premakumara3, Kamal Perera1, Dilani Lokuhetty4, Prasad Katulanda1
1 Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
2 Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka
3 Herbal Technology Division, Industrial Technology Institute, Sri Lanka
4 Department of Pathology, Faculty of Medicine, University of Colombo, Sri Lanka
Correspondence Address:
Priyanga Ranasinghe
Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo
Sri Lanka
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8490.94719
|
|
|
Objectives: To evaluate short- and long-term effects of Cinnamomum zeylanicum on food consumption, body weight, glycemic control, and lipids in healthy and diabetes-induced rats. Materials and Methods: The study was conducted in two phases (Phase I and Phase II), using Sprague-Dawley rats in four groups. Phase I evaluated acute effects on fasting blood glucose (FBG) (Groups 1 and 2) and on post-oral glucose (Groups 3 and 4) blood glucose. Groups 1 and 3 received distilled-water and Groups 2 and 4 received cinnamon-extracts. Phase II evaluated effects on food consumption, body weight, blood glucose, and lipids over 1 month. Group A (n = 8, distilled-water) and Group B (n = 8, cinnamon-extracts) were healthy rats, while Group C (n = 5, distilled-water) and Group D (n = 5, cinnamon-extracts) were diabetes-induced rats. Serum lipid profile and HbA1c were measured on D-0 and D-30. FBG, 2-h post-prandial blood glucose, body weight, and food consumption were measured on every fifth day. Results: Phase I: There was no significant difference in serial blood glucose values in cinnamon-treated group from time 0 (P > 0.05). Following oral glucose, the cinnamon group demonstrated a faster decline in blood glucose compared to controls (P < 0.05). Phase II: Between D0 and D30, the difference in food consumption was shown only in diabetes-induced rats (P < 0.001). Similarly, the significant difference following cinnamon-extracts in FBG and 2-h post-prandial blood glucose from D0 to D30 was shown only in diabetes-induced rats. In cinnamon-extracts administered groups, total and LDL cholesterol levels were lower on D30 in both healthy and diabetes-induced animals (P < 0.001). Conclusions: C. zeylanicum lowered blood glucose, reduced food intake, and improved lipid parameters in diabetes-induced rats. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
